Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic,mmunohistochemical, and Genetic Studies of Four.Cases

摘要

ACQUIRED RETINAL TUMORS CONTAINING BOTH vascular and glial components were first described by Shields and associates in 1983 in a series of 12 cases. Their initial term for this condition was "acquired retinal hemangioma," based on the fluorescein angio-graphic features. Subsequently, the same ocular oncology service reported a series of 103 patients with 129 tumors in 1995; at that time, the authors rechristened the lesions "vasoproliferative tumors of the retina" (VPTR). Many other synonyms have thereafter been employed-"acquired retinal angioma," "angioma-like mass" in retinopathy of prematurity, "retinal angiomatous mass" after retinal detachment surgery, "retinal angiomas in the aged," "angioma-like lesion" in sickle cell disease, "glioangio-sis,"8 "presumed acquired retinal hemangioma," "heman-gioma-like masses of the retina," "peripheral retinal telangiectasia" simulating melanoma, "peripheral uveal neovascularization,"and "neovascular fundus abnormality" in patients with uveitis -all of which share an emphasis on vasogenesis as the essential pathologic substrate. There are, however, few studies on the histopath-ologic features of these lesions upon which to judge their true nature.