Gentamicin-induced Bartter-like syndrome.

摘要

Gentamicin, a widely used antibiotic, is a well-known nephrotoxin responsible for acute nonoli-gouric kidney injury and tubular dysfunction. Among the rarest of these is Bartter-like syndrome, which reportedly occurs in adults and children as a toxic manifestation of gentamicin therapy with unclear pathophysiology. Subclini-cal hypermagnesiuria and hypercalciuria are detected immediately after administering gentamicin. However, the responsible target of gentamicin-associated tubular damage is unclear. This report presents a case of Bartter-like syndrome induced by gentamicin with delayed recovery of as long as 6 weeks and reviews the literature for possible mechanisms of this complication.