Systematic review with meta‐analysis: Lactobacillus rhamnosus Lactobacillus rhamnosus GG for treating acute gastroenteritis in children – a 2019 update

摘要

Summary Background Recently, evidence from a large randomised controlled trial (RCT) negated efficacy of Lactobacillus rhamnosus GG for treating acute gastroenteritis in children. Aim To review RCTs in which L?rhamnosus GG was used to treat acute gastroenteritis in children. Methods The Cochrane Library, MEDLINE, and EMBASE databases were searched from May 2013 (end of last search) to January 2019. The primary outcomes were stool volume and duration of diarrhoea. Results Eighteen RCTs (n?=?4208) were included. Compared with placebo or no treatment, L?rhamnosus GG use had no effect on stool volume but was associated with a reduced duration of diarrhoea (15 RCTs, n?=?3820, mean difference, MD ?0.85?day, 95% CI ?1.15 to ?0.56). L?rhamnosus GG was effective when used at a daily dose of ≥10 10 CFU or 10 10 CFU; however, the latter produced results of borderline significance. L?rhamnosus GG was more effective when used in European countries compared with non‐European countries, particularly when considered by region. L?rhamnosus GG use was associated with a reduced duration of hospitalisation. One RCT found that L?rhamnosus GG had no effect on the total clinical severity score at 14?days after enrolment. Conclusions Despite a recent large RCT demonstrating no effect of L?rhamnosus GG, current evidence shows that, overall, L?rhamnosus GG reduced both the duration of diarrhoea (with a higher impact in European countries) and hospitalisation in inpatients. These findings should be viewed in the context of the high heterogeneity and methodological limitations of the included trials.