Modulation of Lag Time of Sodium Alginate Based Programmed Delivery of Water Soluble Drug from Tablet in Capsule Device

摘要

Three single layered tablets followed by effervescent mixture and lactose, were placed in the insoluble capsule body and soluble cap. Lactose was added as filler while effervescent mixture was used to hasten the release of drug after desired lag time. Two pulse drag release was successfully obtained by placing eudragit S-100 surface coated sodium alginate rate modulating tablet between upper and lower immediate release tablets. Lag time was dependent of thickness of the surface coated sodium alginate tablet, Contrary to previous studies no effect of the amount of lactose was observed on the lag time of drug. Immediate release of the drug was obtained successfully after desired lag time of six h.