Monophosphonic versus Multiphosphonic Acid Based PEGylated Polymers for Functionalization and Stabilization of Metal (Ce, Fe, Ti, Al) Oxide Nanoparticles in Biological Media

Baldim Victor; Bia Nicolas; Graillot Alain; Loubat Cédric; Berret Jean‐Fran?ois

摘要

Abstract > For applications in nanomedicine, particles need to be functionalized to prevent protein corona formation and/or aggregation. Most advanced strategies take advantage of functional polymers and assembly techniques. Nowadays there is an urgent need for coatings that are tailored according to a broad range of surfaces and that can be produced on a large scale. Herein, we synthesize monophosphonic and multiphosphonic acid based poly(ethylene glycol) (PEG) polymers with the objective of producing efficient coats for metal oxide nanoparticles. Cerium, iron, titanium, and aluminum oxide nanoparticles of different morphologies (spheres, platelets, nanoclusters) and sizes ranging from 7 to 40 nm are studied in physiological and in protein rich cell culture media. It is found that the particles coated with monofunctionalized polymers exhibit a mitigated stability over time (1 week), whereas the multifunctionalized copolymers provide resilient coatings and long‐term stability ( months). With the latter, PEG densities in the range 0.2–0.5 nm ?2 and layer thickness about 10 nm provide excellent performances. The study suggests that the proposed coating allows controlling nanomaterial interfacial properties in biological environments. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 对于纳米胺的应用，需要官能化以防止蛋白质电晕形成和/或聚集。大多数先进的策略利用功能性聚合物和组装技术。如今，迫切需要根据宽范围的表面定制的涂层，并且可以大规模生产。在此，我们用氧化金属氧化物纳米粒子的有效涂层合成单膦酸碱和多膦酸基聚（乙二醇）（PEG）聚合物。在生理和蛋白质富含细胞培养基中，研究了不同形貌（球形，血小板，纳米燃烧器）和尺寸的不同形貌（球形，血小板，纳米蛋白）和尺寸的氧化铝纳米粒子。发现涂有单官能化聚合物的颗粒随时间（＆ 1周）具有缓解稳定性，而多官能化共聚物提供弹性涂层和长期稳定性（＆月）。随着后者，PEG密度范围为0.2-0.5nm ？2 </ sup> 并且层厚度约为10nm提供出色的性能。该研究表明，所提出的涂层允许在生物环境中控制纳米材料界面性质。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18063/'>《Advanced materials interfaces》</a> <b style="margin: 0 2px;">|</b><span>2019年第7期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Baldim Victor&option=202" target="_blank" rel="nofollow">Baldim Victor;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bia Nicolas&option=202" target="_blank" rel="nofollow">Bia Nicolas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Graillot Alain&option=202" target="_blank" rel="nofollow">Graillot Alain;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Loubat Cédric&option=202" target="_blank" rel="nofollow">Loubat Cédric;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Berret Jean‐Fran?ois&option=202" target="_blank" rel="nofollow">Berret Jean‐Fran?ois;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Matière et Systèmes ComplexesUMR 7057 CNRS Université Denis Diderot Paris‐VIIBatiment Condorcet 10 rue Alice Domon et Léonie Duquet 75205 Paris France;</p> <p>Specific PolymersZAC Via Domitia150 Avenue des Cocardières 34160 Castries France;</p> <p>Specific PolymersZAC Via Domitia150 Avenue des Cocardières 34160 Castries France;</p> <p>Specific PolymersZAC Via Domitia150 Avenue des Cocardières 34160 Castries France;</p> <p>Matière et Systèmes ComplexesUMR 7057 CNRS Université Denis Diderot Paris‐VIIBatiment Condorcet 10 rue Alice Domon et Léonie Duquet 75205 Paris France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=colloidal stability&option=203" rel="nofollow">colloidal stability;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=functionalization&option=203" rel="nofollow">functionalization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metal oxide nanoparticles&option=203" rel="nofollow">metal oxide nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phosphonic acids&option=203" rel="nofollow">phosphonic acids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surface coating&option=203" rel="nofollow">surface coating;</a> </p> <div class="translation"> 机译：胶体稳定性;功能化;金属氧化物纳米颗粒;膦酸;表面涂层; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022434654.html">Monophosphonic versus Multiphosphonic Acid Based PEGylated Polymers for Functionalization and Stabilization of Metal (Ce, Fe, Ti, Al) Oxide Nanoparticles in Biological Media</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Baldim Victor&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Baldim Victor,</a> <a 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