Effect of particle size on powder compaction and tablet strength using limestone

摘要

Processability of powders in high load compaction constitutes a challenge due to particle rearrangement, compression and breakage occurring simultaneously. Although tableting is a central operation in pharmaceutical technology, a better understanding of the link between the macroscopic powder behaviour and its micro-mechanical properties is still required. In the present study, a dual focus on the powder compaction behaviour and the quality properties of final tablets using a compaction simulator is presented. Tableting has been performed for a wide size range of limestone powders from 10 to 400 MPa, in order to understand and compare the powder compaction behaviour at both low and high confining stresses.