BLOOD PRESSURE PROFILE AND EFFECTS OF ANTIHYPERTENSIVE MEDICATIONS ON BLOOD PRESSURE VARIABILITY IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

摘要

Obstructive sleep apnea (OSA) and hypertension are strongly associated. Most of the studies have shown that diastolic hypertension and non-dipping pattern are more often in these patients. Aim was to investigate the 24 h blood pressure profile in patients through all stages of OSA. Study included adult patients of both genders, hospitalized on Clinic of Pulmology, Clinical center Kragujevac from June to December 2014 for a poligraphy which divided patients into 3 equal groups of 25 patients each stage of OSA and control group without OSA. Ambulatory blood pressure was recorded in all patients for evaluation of blood pressure profile. All data were statistically analyzed by using SPSS for Windows. OSA was more prevalent among male subjects with significant gender-related differences with increasing severity of OSA (p = 0.028). Hypertension was present in approximately 80% in all groups with OSA (p = 0.048). with approximately 70% of patients having antihypertensive therapy. There was a significant difference in diurnal and 24 h systolic and diurnal and 24 h diastolic BP (p = 0.002: p = 0.007: p = 0.019: p = 0.034). OSA is more prevalent in middle-aged male subjects with severity increasing with aging. There was a signficant difference in some blood pressure profile parameters between patients with and without OSA.