Insulin resistance in pregnant women with and without polycystic ovary syndrome, and measures of body composition in offspring at birth and three years of age

Finnbogadóttir Sara K.; Glintborg Dorte; Jensen Tina K.; Kyhl Henriette B.; Nohr Ellen A.; Andersen Marianne

摘要

Abstract <section xml:id="aogs13200-sec-0001"> <title type="main">Introduction >Polycystic ovary syndrome is associated with obesity and insulin?resistance in the non‐pregnant state, but little is known about insulin sensitivity in the pregnant state. Our objective was to compare insulin resistance in pregnant women with and without polycystic ovary syndrome and explore the impact of polycystic ovary syndrome on body composition in offspring at birth and at three years of age. </section> <section xml:id="aogs13200-sec-0002"> <title type="main">Material and methods >A prospective cohort study including 2548 live‐born singleton mother–child pairs residing in Odense municipality, Denmark, during 2010–2013. Of the 2548 women, 241 (9.4%) had polycystic ovary syndrome. </section> <section xml:id="aogs13200-sec-0003"> <title type="main">Results > Homeostatic model assessment for insulin resistance assessments were comparable in women with and without polycystic ovary syndrome. However, the subgroup of overweight women with polycystic ovary syndrome had significantly higher levels of homeostatic model assessment for insulin resistance than overweight women without polycystic ovary syndrome (mean?±?2?SD): 4.4 (3.1) vs. 3.6 (3.4), p? = ? 0.004. Maternal polycystic ovary syndrome did not affect offspring birthweight after accounting for age. However, polycystic ovary syndrome, adjusted for maternal body mass index, was associated with increased body mass index at three years of age (mean?±?2?SD): 16.0 (2.2) vs. 15.7 (2.1)?kg/m 2 , p? = ? 0.04. </section> <section xml:id="aogs13200-sec-0004"> <title type="main">Conclusion >In our cohort, maternal polycystic ovary syndrome was not associated with insulin resistance after correcting for body mass index and was not an independent predictor of offspring birthweight. However, both polycystic ovary syndrome and high maternal body mass index may increase risk of childhood obesity at three years of age. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“aogs13200-abs-0001”> <标题类型=“main”>抽象</ title> <第XML：ID =“AOGS13200-SEC-0001”> <标题类型=“main”>介绍</标题> >多囊卵巢综合征与肥胖和胰岛素相关？在非孕州的抵抗力，但很少以孕州的胰岛素敏感而闻名。我们的目标是将孕妇的胰岛素抵抗与多囊卵巢综合征进行比较，并探讨多囊卵巢综合征对出生后代后代的身体成分的影响。</ p> </ section> <section XML： ID =“AOGS13200-SEC-0002”> <标题类型=“main”>素材和方法</ title> >一项潜在的队列研究，包括2548个现场出生的单身母子对居住在丹麦欧登斯市，期间2010-2013。在2548名女性中，241名（9.4％）具有多囊卵巢综合征。</ p> </ section> <section xml：id =“aogs13200-sec-0003”> <标题类型=“main”>结果</ title> >胰岛素抵抗评估的宿潮模型评估在患有和不具有多囊卵巢综合征的妇女上进行了可比性。然而，具有多囊卵巢综合征的超重女性的超重妇女患者胰岛素抵抗的稳态模型评估显着高于过重女性而没有多囊卵巢综合征（平均值？±2？SD）：4.4（3.1）与3.6（3.4）， p？</ i> = </ i> 0.004。母体多囊卵巢综合征在核算年龄后不会影响后代出生体重。然而，对母体体重指数调整的多囊卵巢综合征与年龄三年的体重指数增加（平均值？±2？SD）：16.0（2.2）与15.7（2.1）？kg / m < sup> 2 </ sup>， p？</ i> = 0.04。 </ p> </ section> <section XML：ID =“AOGS13200-SEC-0004”> <标题类型=“main”>结论</标题> >在我们的队列中，母体多囊卵巢综合征无关矫正体重指数后的胰岛素抵抗，不是后代出生体重的独立预测因素。然而，多囊卵巢综合征和高母体体重指数可能会在三岁时增加儿童肥胖的风险。</ p> </ section> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-17780/'>《Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Finnbogadóttir Sara K.&option=202" target="_blank" rel="nofollow">Finnbogadóttir Sara K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Glintborg Dorte&option=202" target="_blank" rel="nofollow">Glintborg Dorte;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jensen Tina K.&option=202" target="_blank" rel="nofollow">Jensen Tina K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kyhl Henriette B.&option=202" target="_blank" rel="nofollow">Kyhl Henriette B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nohr Ellen A.&option=202" target="_blank" rel="nofollow">Nohr Ellen A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Andersen Marianne&option=202" target="_blank" rel="nofollow">Andersen Marianne;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of EndocrinologyOdense University HospitalOdense Denmark;</p> <p>Department of EndocrinologyOdense University HospitalOdense Denmark;</p> <p>Department of Environmental MedicineOdense University HospitalOdense Denmark;</p> <p>Odense Patient data Explorative Network (OPEN)Odense Denmark;</p> <p>Department of Gynecology and ObstetricsOdense University HospitalOdense Denmark;</p> <p>Department of EndocrinologyOdense University HospitalOdense Denmark;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/197.html" title="妇产科学">妇产科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Polycystic ovary syndrome&option=203" rel="nofollow">Polycystic ovary syndrome;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=insulin resistance&option=203" rel="nofollow">insulin resistance;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=homeostatic model assessment for insulin resistance&option=203" rel="nofollow">homeostatic model assessment for insulin resistance;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pregnancy&option=203" rel="nofollow">pregnancy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=offspring&option=203" rel="nofollow">offspring;</a> </p> <div class="translation"> 机译：多囊卵巢综合征;胰岛素抵抗;胰岛素抵抗的稳态模型评估;怀孕;后代; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022404998.html">Insulin resistance in pregnant women with and without polycystic ovary syndrome, and measures of body composition in offspring at birth and three years of age</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Finnbogadóttir Sara 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2018</span><span>,第019期</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130450889068.html">Derivatives of amidocarboxylic acid, agents for lowering blood glucose, reducing lipid, for improving insulin resistance, anti-inflammatory, for immuno-regulation, for inhibiting aldose reductase, for inhibiting 5-lipoxygenase, for the generation of suppressor of lipid peroxide, to activate ppar, to reduce osteoporosis, and compositions for the therapy or prevention of diabetes mellitus, hyperlipemia, obesity, impaired glucose tolerance, insulin resistance other than igt, liver fatty, diabetic complications, arteriosclerosis, gestational diabetes mellitus, polycystic ovary syndrome, arthroesthesis, rheumatoid arthritis, allergic diseases, asthma, cancer, autoimmune diseases, pancreatitis, and cataracts</a> <b>[P]</b> . <span> 外国专利：  BR9813019A </span> <span> . 2000-09-05</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：酰胺基羧酸的衍生物，用于降低血糖，减少脂质，改善胰岛素抵抗，消炎，用于免疫调节，用于抑制醛糖还原酶，用于抑制5-脂氧合酶，用于产生脂质过氧化物的抑制剂，激活ppar，以减少骨质疏松症，以及用于治疗或预防糖尿病，高脂血症，肥胖症，糖耐量减低，胰岛素抵抗的胰岛素组合物，肝脂肪，糖尿病并发症，动脉硬化，妊娠糖尿病，多囊卵巢综合征，关节置换，类风湿病的组合物关节炎，过敏性疾病，哮喘，癌症，自身免疫性疾病，胰腺炎和白内障 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130442370205.html">METHOD FOR CORRECTING METABOLIC DISORDERS IN CASE OF INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME</a> <b>[P]</b> . <span> 外国专利：  UA65492A </span> <span> . 2004-03-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：多囊卵巢综合征女性胰岛素抵抗情况下代谢紊乱的纠正方法 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130427768908.html">METHOD FOR TREATING INFERTILITY IN WOMEN WITH INSULIN-RESISTANT SYNDROME OF POLYCYSTIC OVARY</a> <b>[P]</b> . <span> 外国专利：  UA50953U </span> <span> . 2010-06-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：多囊卵巢胰岛素抵抗综合征治疗女性不育的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022404998','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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