首页> 外文期刊>Acta Oto-Laryngologica >Ethanol infiltration into the stapedio-vestibular joint reduces low-frequency vibration of the ossicular chain and round window membrane in the guinea pig
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Ethanol infiltration into the stapedio-vestibular joint reduces low-frequency vibration of the ossicular chain and round window membrane in the guinea pig

机译:乙醇浸润进入Stapedio - 前庭关节减少了在豚鼠中的骨齿链和圆形窗膜的低频振动

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摘要

Background: The synovial stapedio-vestibular joint (SVJ), which serves as a bridge between the stape and oval window, can be found in guinea pigs and most human adults. Unlike the fibrous SVJs in other animals, the contribution of the synovial SVJ to middle ear sound transmission remains unknown. Aims/objectives: In this study, we investigate whether sclerosis of the synovial SVJ contributes to frequency-dependent vibration of the ossicular chain and round window membrane (RWM). Materials and methods: A model of SVJ sclerosis model was established in the guinea pig using 75% ethanol. A laser Doppler vibrometer was then used to measure vibrations of the RWM and the long process of the incus (LPI) under pure tone sound stimulations of 0.25-16 kHz. The influence of SVJ sclerosis was analysed by comparing structural vibration displacement between the normal and sclerosis groups. Results: Both LPI and RWM vibrations significantly decreased at low frequencies after infiltration of ethanol, which caused SVJ sclerosis. Conclusions: SVJ sclerosis reduces low-frequency vibration of the ossicular chain and RWM in the guinea pig, which indicates that the synovial SVJ is vital to low-frequency sound transmission in the middle ear.
机译:背景:滑膜stapedio - 前庭接头(SVJ),它可以在豚鼠和大多数人类成年人中发现。与其他动物的纤维SVJS不同,滑膜SVJ对中耳声音变速器的贡献仍然未知。旨在/目标:在本研究中,我们研究了滑膜SVJ的硬化是否有助于骨折链和圆形窗膜(RWM)的频率依赖性振动。材料与方法:使用75%乙醇在豚鼠中建立了SVJ硬化模型的模型。然后使用激光多普勒振动计测量RWM的振动和INCUS(LPI)的纯净音响刺激在0.25-16 kHz的振动。通过比较正常和硬化群体之间的结构振动位移来分析SVJ硬化的影响。结果:乙醇渗透后,LPI和RWM振动在低频下显着降低,这导致SVJ硬化。结论:SVJ硬化减少了豚鼠中的骨齿链和RWM的低频振动,表明滑膜SVJ对中耳的低频声速变速器至关重要。

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