Lifestyle changes in cancer patients undergoing curative or palliative chemotherapy: is it feasible?

摘要

Introduction: This study aimed to explore the feasibility of an individualized comprehensive lifestyle intervention in cancer patients undergoing curative or palliative chemotherapy.Material and methods: At one cancer center, serving a population of 180,000, 100 consecutive of 161 eligible newly diagnosed cancer patients starting curative or palliative chemotherapy entered a 12-month comprehensive, individualized lifestyle intervention. Participants received a grouped startup course and monthly counseling, based on self-reported and electronically evaluated lifestyle behaviors. Patients with completed baseline and end of study measurements are included in the final analyses. Patients who did not complete end of study measurements are defined as dropouts.Results: More completers (n=61) vs. dropouts (n=39) were married or living together (87 vs. 69%, p=.031), and significantly higher baseline physical activity levels (960 vs. 489min(.)wk(-1), p=.010), more healthy dietary choices (14 vs 11 points, p=.038) and fewer smokers (8 vs. 23%, p=.036) were observed among completers vs. dropouts. Logistic regression revealed younger (odds ratios (OR): 0.95, 95% confidence interval (CI): 0.91, 0.99) and more patients diagnosed with breast cancer vs. more severe cancer types (OR: 0.16, 95% CI: 0.04, 0.56) among completers vs. dropouts. Improvements were observed in completers healthy (37%, p0.001) and unhealthy dietary habits (23%, p=.002), and distress (94%, p.001). No significant reductions were observed in physical activity levels. Patients treated with palliative intent did not reduce their physical activity levels while healthy dietary habits (38%, p=0.021) and distress (104%, p=0.012) was improved.Discussion: Favorable and possibly clinical relevant lifestyle changes were observed in cancer patients undergoing curative or palliative chemotherapy after a 12-month comprehensive and individualized lifestyle intervention. Palliative patients were able to participate and to improve their lifestyle behaviors.