Cardiovascular epigenome-wide association studies: is epigenetics falling short?

摘要

BJUT-II VAD (Beijing University of Technology ventricular assist device II) is a novel left ventricular assist device. Because of the special connection between the pump and native heart, the hemodynamic effects of BJUT-II VAD on coronary artery are still unclear. Hence, numerical simulations have been conducted to clarify changes in hemodynamic effects of different support modes. A patient-specific left coronary arterial geometric model is reconstructed based on the computed tomography (CT) data. Three support modes, "constant speed mode," "co-pulse mode," and "counter pulse mode," are used in this study. The wall shear stress (WSS), wall shear stress gradient (WSSG), cycle-averaged wall shear stress (avWSS), oscillatory shear index (OSI), and the flow pattern are calculated to evaluate the hemodynamic states of coronary artery. The computational results demonstrate that the hemodynamic states of coronary artery are directly affected by the support modes. The co-pulse modes could achieve the highest blood perfusion (constant speed: 153 ml/min vs. co-pulse: 775 ml/min vs. counter pulse: 140 ml/min) and the highest avWSS (constant speed: 18.1 Pa vs. co-pulse: 42.6 Pa vs. counter pulse: 22.6 Pa). In addition, both the WSS and WSSG at the time of peak blood velocity under the constant speed mode are lower than those under other two support modes. In contrast, the counter pulse mode generates the highest OSI value (constant speed: 0.365 vs. co-pulse: 0.379 vs. counter pulse: 0.426). BJUT-II VAD under co-pulse mode may have benefits for improving coronary perfusion and preventing the development of atherosclerosis; however, the constant speed mode may have benefit for preventing the development of plaque vulnerability.