Repurposing of Fluvastatin Against Candida albicans CYP450 Lanosterol 14 alpha-demethylase, a Target Enzyme for Antifungal Therapy: An In silico and In vitro Study

摘要

Background: The incidence of fungal infections has increased significantly. Specifically the cases of candida albicans infection are increasing day by day and their resistance to clinically approved drugs is a major concern for humans. Various classes of antifungal drugs are available in the market for the treatment of these infections but unfortunately, none of them is able to treat the infection.