Combining High Speed ELM Learning with a Deep Convolutional Neural Network Feature Encoding for Predicting Protein-RNA Interactions

摘要

Emerging evidence has shown that RNA plays a crucial role in many cellular processes, and their biological functions are primarily achieved by binding with a variety of proteins. High-throughput biological experiments provide a lot of valuable information for the initial identification of RNA-protein interactions (RPIs), but with the increasing complexity of RPIs networks, this method gradually falls into expensive and time-consuming situations. Therefore, there is an urgent need for high speed and reliable methods to predict RNA-protein interactions. In this study, we propose a computational method for predicting the RNA-protein interactions using sequence information. The deep learning convolution neural network (CNN) algorithm is utilized to mine the hidden high-level discriminative features from the RNA and protein sequences and feed it into the extreme learning machine (ELM) classifier. The experimental results with 5-fold cross-validation indicate that the proposed method achieves superior performance on benchmark datasets (RPI1807, RPI2241, and RPI369) with the accuracy of 98.83, 90.83, and 85.63 percent, respectively. We further evaluate the performance of the proposed model by comparing it with the state-of-the-art SVM classifier and other existing methods on the same benchmark data set. In addition, we predicted the independent NPInter v2.0 data set using the model trained on RPI369. The experimental results show that our model can serve as a useful tool for predicting RNA-protein interactions.