Active Amyloid-beta Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model

摘要

Background: While evidence accumulates for a role of epigenetic modifications in the pathophysiological cascade of Alzheimer's disease (AD), amyloid-beta (A beta)-targeted active immunotherapy approaches are under investigation to prevent or slow the progression of AD. The impact of A beta active vaccines on epigenetic markers has not been studied thus far.