Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone (R) and estradiol: pharmacokinetics from a dose-finding study

Jensen J. T.; Edelman A. B.; Chen B. A.; Archer D. F.; Barnhart K. T.; Thomas M. A.; Burke A. E.; Westhoff C. L.; Wan L. S.; Sitruk-Ware R.; Kumar N.; Variano B.; Blithe D. L.

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Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone (R) and estradiol: pharmacokinetics from a dose-finding study

机译：连续给药一种新型避孕阴道环释放Nestorone（R）和雌二醇：药代动力学来自剂量查找研究

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Background: As part of a program to develop a novel estradiol-releasing contraceptive vaginal ring (CVR), we evaluated the pharmacokinetic (PK) profile of CVRs releasing segesterone acetate (Nestorone (R) (NES)) combined with one of three different estradiol (E-2) doses.

机译：背景：作为开发新型雌二醇释放避孕阴道环（CVR）的程序的一部分，我们评估了CVRS的药代动力学（PK）曲线释放Segestone乙酸酯（Nestorone（R）（NES））与三种不同的雌二醇中的一种组合（E-2）剂量。

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来源
《Contraception》 |2018年第5期|共6页
作者
Jensen J. T.; Edelman A. B.; Chen B. A.; Archer D. F.; Barnhart K. T.; Thomas M. A.; Burke A. E.; Westhoff C. L.; Wan L. S.; Sitruk-Ware R.; Kumar N.; Variano B.; Blithe D. L.;
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作者单位

Oregon Hlth &

Sci Univ Dept Obstet &

Gynecol Portland OR 97201 USA;

Oregon Hlth &

Sci Univ Dept Obstet &

Gynecol Portland OR 97201 USA;

Univ Pittsburgh Sch Med Magee Womens Res Inst Dept Obstet Gynecol &

Reprod Sci Pittsburgh PA;

Eastern Virginia Med Sch Dept Obstet &

Gynecol Norfolk VA 23501 USA;

Univ Penn Sch Med Dept Obstet &

Gynecol Penn Clin Res Ctr Philadelphia PA 19104 USA;

Univ Cincinnati Coll Med Dept Obstet &

Gynecol Reprod Med Res Cincinnati OH 45267 USA;

Johns Hopkins Univ Sch Med Dept Gynecol &

Obstet Baltimore MD 21205 USA;

Columbia Univ Coll Phys &

Surg Dept Obstet &

Gynecol New York NY 10032 USA;

NYU Dept Obstet &

Gynecol Sch Med New York NY 10016 USA;

Populat Council Ctr Biomed Res 1230 York Ave New York NY 10021 USA;

Populat Council Ctr Biomed Res 1230 York Ave New York NY 10021 USA;

Populat Council Ctr Biomed Res 1230 York Ave New York NY 10021 USA;

Eunice Kennedy Shriver Natl Inst Child Hlth &

Hum Contracept Dev Program Bethesda MD USA;

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原文格式 PDF
正文语种 eng
中图分类个人卫生;
关键词
Contraceptive vaginal ring; Nestorone; Estradiol; Pharmacokinetics; Contraception; Continuous cycling;

机译：避孕阴道环;Nestorone;雌二醇;药代动力学;避孕;连续循环;

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专利

1. Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone (R) and estradiol: pharmacokinetics from a dose-finding study [J] . Jensen J. T., Edelman A. B., Chen B. A., Contraception . 2018,第5期

机译：连续给药一种新型避孕阴道环释放Nestorone（R）和雌二醇：药代动力学来自剂量查找研究
2. Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone (R) (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: a randomized, crossover drug-drug interaction study [J] . Simmons Katharine B., Kumar Narender, Plagianos Marlena, Contraception . 2018,第3期

机译：同时阴道胶凝唑处理对避孕阴道环携带（乙酸盐醋酸酯）和乙炔雌二醇的吸收和暴露的影响：随机交叉药物 - 药物相互作用研究
3. Phase II dose-finding study on ovulation inhibition and cycle control associated with the use of contraceptive vaginal rings containing 17 beta-estradiol and the progestagens etonogestrel or nomegestrol acetate compared to NuvaRing [J] . Duijkers Ingrid, Klipping Christine, Heger-Mahn Doris, The European journal of contraception & reproductive health care: the official journal of the European Society of Contraception . 2018,第4期

机译：相对于含有17β-雌二醇的避孕阴道环和醋酸雌激素或Nomegestrol乙酸酯的使用避孕阴道环的排卵抑制和循环对照的研究II剂量发现研究
4. Sustained release of protease inhibitors from silicone elastomer vaginal rings as a potential strategy for the prevention of vaginal transmission of HIV [C] . Susan M. Fetherston, R. Karl Malcolm, A. David Woolfson, Annual meeting exposition of the Controlled Release Society . 2010

机译：从硅橡胶弹性体阴道环中持续释放蛋白酶抑制剂是预防HIV阴道传播的潜在策略
5. Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors. [D] . Fahmy, Sahar Abd El-Sattar. 2004

机译：硝苯地平新型喷雾包衣的软弹性明胶胶囊缓释制剂的开发，维拉帕米盐酸盐控释制剂的生物利用度和生物等效性，在猛禽中单次口服剂量后特比萘芬的药代动力学。
6. Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone® and estradiol: pharmacokinetics from a dose-finding study [O] . J. T. Jensen, A. B. Edelman, B. A. Chen, -1

机译：连续服用新型避孕药阴道环释放Nestorone®和雌二醇：一项剂量研究的药代动力学
7. Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone® and estradiol: pharmacokinetics from a dose-finding study [O] . J.T. Jensen, A.B. Edelman, B.A. Chen, 2018

机译：连续给药一种新型避孕阴道环释放Nestorone®和雌二醇：药代动力学来自剂量查找研究

Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone (R) and estradiol: pharmacokinetics from a dose-finding study

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