Foxtrot Collaborative Group (2012) Lancet Oncol 13:1152-60 Feasibility of Preoperative Chemotherapy for Locally Advanced, Operable Colon Cancer: the Pilot Phase of a Randomised Controlled Trial

摘要

Background: Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps because of more effective micrometastasis eradication and reduced risk of incomplete excision and tumour cell shedding during surgery. The Foxtrot trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer.