Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide

摘要

Graphical abstractDisplay OmittedHighlights?The high surface potential improved the cell uptake of the chitosan-modified nanoparticles (CS@PLGA NPs).?The composite nanoparticles improved the hypoglycemic effect of tolbutamide.?The novel nanoparticles avoided the gastrointestinal reaction of tolbutamide.AbstractThe main purpose of present study was to develop novel chitosan-modified polylactic-co-glycolicacid nanoparticles (CS@PLGA NPs) for improving the bio-availability of tolbutamide (TOL). The TOL-loaded CS@PLGA NPs (TOL-CS@PLGA NPs) were fabricated with the solvent evaporation method. The cargo-free CS@PLGA NPs showed a diameter of 228.3±2.5nm monitored with a laser light particlesizer, and the transm