Performance comparison of two herbal and industrial medicines using nanoparticles with a starch/cellulose shell and alginate core for drug delivery: In vitro studies

摘要

Graphical abstractPreparation nanoparticles with the shell of starch/cellulose and the core of alginate/drug nano drug carriers help to ossification by placement in porous bone. The properties of nanoparticles were studied by SEM(Scanning electron microsphere) and optimization by Response Surface Methodology(RSM).Display OmittedHighlights?Preparation nanoparticles with the starch/cellulose shell and core of alginate.?Two kinds of industrial and herbal drugs in nanoparticles was examined.?In vitro drug release of drugs was investigated in SBF and PBS.?Use optimization of the test steps by RSM was examined for polymer concentration and pH.AbstractIn this study, the performance of two kinds of industrial and herbal drugs encapsulated in nanoparticles with a shell of starch and cellulose and an alginate core were examined as a new technique for nanoparticle drug delivery. The test method involved creating a suspension of starch and alginate, which was then dried, mixed with cellulose, and heated to form core-shell nanoparticles. The industrial drug calcitonin and an extract of the herbAmaranthus retroflexcusL. were added separately and in combination to the nanoparticles, and the performance of each configuration was evaluated. Variables like shape, size of nanoparticle, and pH were examined for their effect in vitro. Response surface methodology (RSM) was employed for optimization of parameters. The properties of the nanoparticles were studied by scanning electron microscopy (SEM) and Ultraviolet–visible spectroscopy (UV–vis). The most optimal conditions for formation of the smallest nanoparticles were found to be pH 4 with a concentration of 0.15g starch, 0.04g alginate, and 0.01g cellulose, which resulted in a spherical nanoparticle size of 25.6–68.7nm. This novel method for helping bone regeneration offers a potentially major advance in the medical treatment of osteoporosis. The results of optimization indicated that the most optimal conditions of the tests were performed at pH 4, CA=0.04, CS=0.21, and CC=0.01. In acidic pH the size of nanoparticles was less than 100nm.]]>