ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases

Kumthekar Priya; Tang Shou-Ching; Brenner Andrew J.; Kesari Santosh; Piccioni David E.; Anders Carey; Carrillo Jose; Chalasani Pavani; Kabos Peter; Puhalla Shannon; Tkaczuk Katherine; Garcia Agustin A.; Ahluwalia Manmeet S.; Wefel Jeffrey S.; Lakhani Nehal; Ibrahim Nuhad

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases

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ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases

机译：Ang1005是一种脑穿透肽 - 药物缀合物，显示出患有乳腺癌患者的患者的活性，患有脑癌癌细胞病和复发性脑转移

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Purpose: ANG1005, a novel taxane derivative, consists of three paclitaxel molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via LRP1 transport system. Preclinical and clinical evidence of efficacy with ANG1005 has been previously shown.

机译：目的：ang1005是一种新型紫杉烷衍生物，由三个紫杉醇分子组成，所述紫杉醇分子与血管缺陷2均等，设计用于通过LRP1运输系统穿过血脑和血液脑脊屏障并渗透恶性细胞。先前显示了与Ang1005有效的临床前和临床证据。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2020年第12期|共11页
作者
Kumthekar Priya; Tang Shou-Ching; Brenner Andrew J.; Kesari Santosh; Piccioni David E.; Anders Carey; Carrillo Jose; Chalasani Pavani; Kabos Peter; Puhalla Shannon; Tkaczuk Katherine; Garcia Agustin A.; Ahluwalia Manmeet S.; Wefel Jeffrey S.; Lakhani Nehal; Ibrahim Nuhad;
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作者单位

Northwestern Univ Feinberg Sch Med 675 N St Clair St Galter 20th Floor Chicago IL 60611 USA;

Univ Mississippi Med Ctr Canc Ctr Jackson MS 39216 USA;

UT Hlth San Antonio Mays Canc Ctr San Antonio TX USA;

John Wayne Canc Inst Santa Monica CA USA;

Univ Calif San Diego Moores Canc Ctr Dept Neurosci La Jolla CA USA;

Duke Canc Inst Durham NC USA;

Providence St Johns Hlth Ctr John Wayne Canc Inst Santa Monica CA USA;

Univ Arizona Canc Ctr Tucson AZ USA;

Univ Colorado Anschutz Med Campus Greenwood Village CO USA;

Univ Pittsburgh Magee Womens Canc Program Pittsburgh PA USA;

Univ Maryland Greenebaum Comprehens Canc Ctr Baltimore MD 21201 USA;

Louisiana State Univ New Orleans LA USA;

Cleveland Clin Miller Family Endowed Chair Neurooncol Cleveland OH 44106 USA;

Univ Texas MD Anderson Canc Ctr Dept Neurooncol Houston TX 77030 USA;

Canc &

Hematol Ctr Western Michigan Grand Rapids MI USA;

Univ Texas MD Anderson Canc Ctr Div Canc Med Dept Breast Med Oncol Houston TX 77030 USA;

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正文语种 eng
中图分类肿瘤学;
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1. ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases [J] . Kumthekar Priya, Tang Shou-Ching, Brenner Andrew J., Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第12期

机译：Ang1005是一种脑穿透肽 - 药物缀合物，显示出患有乳腺癌患者的患者的活性，患有脑癌癌细胞病和复发性脑转移
2. Incidence and Risk Factors for Leptomeningeal Carcinomatosis in Breast Cancer Patients with Parenchymal Brain Metastases [J] . Jung Jong-myung, Kim Sohee, Joo Jungnam, Journal of Korean Neurosurgical Society . 2012,第3期

机译：患有实质性脑转移的乳腺癌患者软脑膜癌的发病率和危险因素
3. DEGRO Practical Guidelines for palliative radiotherapy of breast cancer patients: brain metastases and leptomeningeal carcinomatosis. [J] . Feyer P, Sautter Bihl ML, Budach W, Strahlentherapie und Onkologie . 2010,第2期

机译：DEGRO乳腺癌患者姑息放疗实用指南：脑转移和软脑膜癌。
4. Expression analysis and mass spectrometric structure characterization reveals unknown ezrin truncations in lymph node metastases of breast cancer patients [C] . Claudia Rower, Christian George, Toralf Reimer, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：表达分析和质谱结构表征揭示乳腺癌患者淋巴结转移中未知的Ezrin截短
5. Developing Induced Neural Stem Cell Therapy to Treat Triple-Negative Breast Cancer and Brain Metastases [D] . Jiang, Wulin. 2021

机译：诱导神经干细胞疗法治疗三阴性乳腺癌和脑转移
6. OS7.2 A Phase II Study of ANG1005 a novel BBB/BCB Penetratant Taxane in Patients with Recurrent Brain Metastases and Leptomeningeal Carcinomatosis from Breast Cancer [O] . P. Kumthekar, S. Tang, A. J. Brenner, 2016

机译：OS7.2 A对新型BBB / BCB穿透性紫杉烷类ANG1005的II期研究用于患有乳腺癌的复发性脑转移和软脑膜癌
7. OS7.2 A Phase II Study of ANG1005, a novel BBB/BCB Penetratant Taxane in Patients with Recurrent Brain Metastases and Leptomeningeal Carcinomatosis from Breast Cancer [O] . P. Kumthekar, S. Tang, A. J. Brenner, 2016

机译：OS7.2 AIC ANG1005的研究，一种新的BBB / BCB穿透剂紫杉烷患者，患有乳腺癌的脑转移和脑膜脑癌癌
8. F18 EF5 PET/CT Imaging in Patients with Brain Metastases from Breast Cancer. [R] . Lin, L. 2014

机译：F18 EF5 pET / CT显像对乳腺癌脑转移患者的影响。

ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases

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