TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

Rivoltini Licia; Chiodoni Claudia; Squarcina Paola; Tortoreto Monica; Villa Antonello; Vergani Barbara; Buerdek Maja; Botti Laura; Arioli Ivano; Cova Agata; Mauri Giorgio; Vergani Elisabetta; Bianchi Beatrice; Della Mina Pamela; Cantone Laura; Bollati Valentina; Zaffaroni Nadia; Gianni Alessandro Massimo; Colombo Mario Paolo; Huber Veronica

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

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TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

机译：相关的凋亡诱导配体（TRAIL） - 用于肿瘤部位的促使外来辐射信号

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Purpose: Exosomes deliver signals to target cells and could thus be exploited as an innovative therapeutic tool. We investigated the ability of membrane TRAIL-armed exosomes to deliver proapoptotic signals to cancer cells and mediate growth inhibition in different tumor models.

机译：目的：外来物体向靶细胞输送信号，因此可以被利用为一种创新的治疗工具。我们调查了膜径武装外来物体将促使信号递送给癌细胞的能力，并在不同肿瘤模型中调解生长抑制。

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来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第14期|共14页
作者
Rivoltini Licia; Chiodoni Claudia; Squarcina Paola; Tortoreto Monica; Villa Antonello; Vergani Barbara; Buerdek Maja; Botti Laura; Arioli Ivano; Cova Agata; Mauri Giorgio; Vergani Elisabetta; Bianchi Beatrice; Della Mina Pamela; Cantone Laura; Bollati Valentina; Zaffaroni Nadia; Gianni Alessandro Massimo; Colombo Mario Paolo; Huber Veronica;
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作者单位

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Immunol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Pharmacol Unit Milan Italy;

Univ Milano Bicocca Consorzio MIA Microscopy &

Image Anal Milan Italy;

Univ Milano Bicocca Consorzio MIA Microscopy &

Image Anal Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Immunol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Immunol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Immunol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

Univ Milano Bicocca Consorzio MIA Microscopy &

Image Anal Milan Italy;

Univ Milan EPIGET Dept Clin Sci &

Community Hlth Epidemiol Epigenet &

Toxicol Lab Milan Italy;

Univ Milan EPIGET Dept Clin Sci &

Community Hlth Epidemiol Epigenet &

Toxicol Lab Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Pharmacol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Med Oncol Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Mol Immunol Unit Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Expt Oncol &

Mol Med Unit Immunotherapy Human Tumors Milan Italy;

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正文语种 eng
中图分类肿瘤学;
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专利

1. TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site [J] . Rivoltini Licia, Chiodoni Claudia, Squarcina Paola, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第14期

机译：相关的凋亡诱导配体（TRAIL） - 用于肿瘤部位的促使外来辐射信号
2. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor [J] . Shohei Koyama, Naoto Koike, Shinya Adachi Journal of Cancer Research and Clinical Oncology . 2002,第2期

机译：肿瘤坏死因子相关凋亡诱导配体（TRAIL）及其受体在胃癌和肿瘤浸润淋巴细胞中的表达：肿瘤免疫逃逸的可能机制。
3. The Transcription Factor Wilms Tumor 1 Confers Resistance in Myeloid Leukemia Cells against the Proapoptotic Therapeutic Agent TRAIL (Tumor Necrosis Factor α-related Apoptosis-inducing Ligand) by Regulating the Antiapoptotic Protein Bcl-xL [J] . Hima Bansal, Theresea Seifert, Carlos Bachier, The Journal of biological chemistry . 2012,第39期

机译：通过调节抗透露蛋白Bcl-XL，转录因子肿瘤1对蛋白酶白血病细胞（肿瘤坏死因子α相关凋亡诱导配体）的抗性诱导骨髓性白血病细胞
4. TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH [C] . OLIVIER MEURETTE, LAURENCE HUC, AMELIE REBILLARD, International Conference on Natural Products and Molecular Medicine . 2005

机译：TRAIL（与TNF相关的凋亡诱导配体）在酸性细胞外pH下诱导肿瘤细胞中的坏死状细胞死亡
5. TNF-related apoptosis-inducing ligand (TRAIL/Apo-2L): A novel mechanism for CpG ODN and BCG-induced anti-tumor activity. [D] . Kemp, Troy Jon. 2005

机译：TNF相关凋亡诱导配体（TRAIL / Apo-2L）：CpG ODN和BCG诱导的抗肿瘤活性的新机制。
6. TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation [O] . Men-Luh Yen, Ping-Ning Hsu, Hsiu-Jung Liao, 2009

机译：TRAF-6依赖的信号通路对于TNF相关的凋亡诱导配体（TRAIL）诱导破骨细胞分化至关重要。
7. TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation [O] . Yen, Men-Luh, Hsu, Ping-Ning, Liao, Hsiu-Jung, 2012

机译：TRAF-6依赖的信号通路对于TNF相关的凋亡诱导配体（TRAIL）诱导破骨细胞分化至关重要。
8. Modulators of Response to Tumor Necrosis-Related Apoptosis-Inducing Ligand (TRAIL) Therapy in Ovarian Cancer [R] . Behbakht, K. 2009

机译：肿瘤坏死相关凋亡诱导配体（TRaIL）治疗卵巢癌的调节因子

TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

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