A Predictor of Early Disease Recurrence in Patients With Breast Cancer Using a Cell-free RNA and Protein Liquid Biopsy

摘要

To assist clinicians with treatment decisions for patients with breast cancer, we investigated whether the preoperative plasma levels of RNAs and the protein cancer antigen 15-3 were associated with prognosis. We identified a novel biomarker, microRNA-923, and combined this with cancer antigen 15-3 and clinicopathological features to build a multivariable model predictive of prognosis, irrespective of treatment, in 253 patients with breast cancer.