Long-Term Survival Differences Between T1-2 Invasive Lobular Breast Cancer and Corresponding Ductal Carcinoma After Breast-Conserving Surgery: A Propensity-Scored Matched Longitudinal Cohort Study

摘要

The Surveillance, Epidemiology, and End Results (SEER) Program was used to compare survival and local recurrence risk (LR) in patients with 2 histologic types of disease-invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC)-receiving breast-conserving surgery (BCS). Patients with T1-2 ILC were less likely to undergo BCS and had better overall survival compared to patients with IDC, but they had worse second primary cancer-free survival and higher LR than those of patients with IDC in the nuclear grade III subgroup. Continuing efforts to identify a subset of subjects with T1-2 ILC of nuclear grade III is contraindicated for BCS in further clinical trials.