Unbalanced translocation der(7)t(7q;11q): A new recurrent aberration leading to partial monosomy 7q and trisomy 11q in acute myeloid leukemia

摘要

Unbalanced translocations, which are created if one of the two derivative chromosomes is lost, often result in the loss or gain of chromosomal material rather than the formation of fusion genes in hematological malignancies [1]. They are usually part of complex karyotypes, diag-nostically nonspecific and related to disease progression, although some of them seem to be a recurrent and primary anomaly [2,3]. Recently, unbalanced translocations involving chromosome 11, such as der(18)t(11;18) (q13;q21.1) and der(7)t(7;11)(q31;ql4), have been reported in acute myeloid leukemia (AML) [4, 5]. These translocations occurred as a sole abnormality at diagnosis, and resulted in partial trisomy 11q including three copies of the MLL gene at 11q23. Here, we describe a new case of AML with der(7)t(7q;11q), which led to partial monosomy 7q and partial trisomy 11q including MLL.