Erylosides F-8, V-1-V-3, and W-W-2 - New triterpene oligoglycosides from the Carribean sponge Erylus goffrilleri

摘要

Seven new triterpene glycosides, erylosides F-8 (1), V-1 (2), V-2 (3), V-3 (4), W (5), W-1 (6) and W-2 (7), were isolated from a Carribean sponge Erylus goffrilleri collected from the Carribean Sea near the Arrecife-Seco reef (Cuba). Structures of the glycosides were determined using H-1 and C-13 NMR spectroscopy, including 2D NMR procedures (H-1-H-1 COSY, H-1-C-13 HMBC, H-1-C-13 HSQC and NOESY) and HR ESI mass spectrometry. Erylosides 1 and 4 have 14-carboxy-24,25-dimethyllanost-8(9)-en-3 beta, 25-diol as aglycone whereas glycosides 2, 3, 5, 6 and 7 are 14-carboxy-24-acetoxy-24-methyllanost-8(9)-en-3 beta-ol glycoconjugates. Cytotoxic activities of the isolated compounds against Ehrlich carcinoma cells and hemolysis were examined and their dependence on eryloside structure was evaluated. (C) 2017 Published by Elsevier Ltd.