A Facile Approach to Carbon Dots‐Mesoporous Silica Nanohybrids and Their Applications for Multicolor and Two‐Photon Imaging Guided Chemo‐/Photothermal Synergistic Oncotherapy

摘要

Abstract > Multifunctional nanocarrier‐based theranostics have been proposed to overcome some key problems in cancer treatments. In this contribution, a facile approach is reported to synthesize carbon dots‐mesoporous silica nanohybrids (named MSNs‐CDs) via a one‐pot microwave heating reaction of amino‐functionalized mesoporous silica nanoparticles (MSNs‐NH <sub>2</sub> ) and citric acid in formamide. The MSNs‐CDs nanohybrids exhibit capabilities of multicolor/two‐photon imaging, high photothermal conversion under NIR laser irradiation (671?nm), and anti‐cancer drug delivery, and thus could potentially be applied as a multifunctional nanocarrier‐based theranostic agent for cancer. Further studies revealed that CDs were in?situ formed on the surface of MSNs during the reaction, which is amenable for the observed multicolor/two‐photon imaging and photothermal properties. Besides, the well‐preserved MSNs characters of MSNs‐CDs nanohybrids (e.?g., mesoporous structure, large surface area and pore volume) enable them to be an ideal nanocarrier for delivering anti‐cancer drugs, such as doxorubicin (DOX). Importantly, the MSNs‐CDs@DOX exhibited pH‐ (lower pH being preferred) and thermo‐responsive DOX release behaviors, which would effectively decrease side effects and meanwhile enhance the efficacy of chemotherapy due to the weak acidic microenvironment of tumor and photothermal effect of the CDs. Finally, in?vitro experiments exhibited that the highest therapeutic efficacy was obtained by MSNs‐CDs@DOX with NIR irradiation, attributing to the synergistic effect of chemotherapy and PTT. This study not only provides a facile method to prepare CDs and MSNs nanohybrids, but also demonstrates that both of the superior features and functions of CDs and MSNs could be preserved and combined, which are deemed to be beneficial for the development of multifunctional theranostic nanoplatform for cancers. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 已经提出了多功能纳米载波的托管学，以克服癌症治疗中的一些关键问题。在这种贡献中，据报道，通过氨基官能化的介孔二氧化硅纳米粒子（MSNS-NH）的单罐微波加热反应（MSN-NH <sub> 2 </ sub> ）甲酰胺中的柠檬酸。 MSNS-CDS纳米组织表现出多色/双光子成像的能力，在NIR激光照射下的高光热转化（671Ω·NM）和抗癌药物递送，因此可能施加为基于多功能纳米载体的治疗剂癌症。进一步的研究表明，在反应过程中，CD在MSN的表面上形成的原位，其适用于观察到的多色/双光子成像和光热性能。此外，保存的MSN-CD纳米嗜含量的MSNS特征（例如，中孔结构，大表面积和孔体积）使其能够成为抗癌药物的理想纳米载体，例如多柔比星（DOX）。重要的是，MSNS-CDS @ DOX发挥了pH-（优选的pH值）和热响应性DOX释放行为，这将有效地降低副作用，同时增强了化疗的功效由于肿瘤弱酸性微环境和光热效应CD。最后，在体外实验中表现出最高的治疗效果是通过MSNS-CDS @ dox获得的，归因于化学疗法和PTT的协同作用。该研究不仅提供了制备CD和MSN纳米胺的容易方法，而且还证明了CD和MSN的卓越特征和功能，可以保存和组合，其被认为是有益于开发多功能治疗纳米纳薄形状的癌症。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16168/'>《ChemNanoMat》</a> <b style="margin: 0 2px;">|</b><span>2020年第6期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1676.html" title="工程材料学">工程材料学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carbon dots&option=203" rel="nofollow">carbon dots;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mesoporous silica nanoparticles&option=203" rel="nofollow">mesoporous silica nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multifunctional theranostic nanoplatform&option=203" rel="nofollow">multifunctional theranostic nanoplatform;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug delivery&option=203" rel="nofollow">drug delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multicolor/two-photon imaging&option=203" rel="nofollow">multicolor/two-photon imaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=synergistic oncotherapy&option=203" rel="nofollow">synergistic oncotherapy;</a> </p> <div class="translation"> 机译：碳点;中孔二氧化硅纳米颗粒;多官能治疗纳米粒状物;药物递送;多色/双光子成像;协同疗法; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab 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