Hypocrellin Derivative-Loaded Calcium Phosphate Nanorods as NIR Light-Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

摘要

Dopamine modified hypocrellin B(DAHB)derivative-loaded calcium phosphate nanorods(DAHB@CaP NRs)were prepared as a novel phototheranostic agent for effective tumor imaging and therapy.DAHB@CaP NRs were obtained through microwave treatment using DAHB,CaCl2,NH3·H2O,and H3PO4 as precursors.The DAHB@CaP NRs possessed the following advantages:1)efficient absorption in the near-infrared(NIR)region from 650 nm to 800 nm;2)maximum NIR emission at approximately 735 nm;3)enhanced cellular uptake efficiency in vitro and in vivo;and 4)efficient inhibition of tumor growth and low biotoxicity.These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence(FL)imagingguided photodynamic therapy of cancer,thus offering promising new prospects for clinical applications.