Fabrication of Mesoporous‐Silica‐Coated Upconverting Nanoparticles with Ultrafast Photosensitizer Loading and 808?nm NIR‐Light‐Triggering Capability for Photodynamic Therapy

Han Renlu; Shi Junhui; Liu Zongjun; Wang Hao; Wang You

摘要

Abstract >A novel photodynamic therapy nanoplatform based on mesoporous‐silica‐coated upconverting nanoparticles (UCNP) with electrostatic‐driven ultrafast photosensitizer (PS) loading and 808?nm near infrared (NIR)‐light‐triggering capabilities has been fabricated. By positively charging inner channels of the mesoporous silica shell with amino groups, a quantitative dosage of negatively charged PS, exemplified with Rose Bengal (RB) molecules, can be loaded in 2?min. In addition, the electrostatic‐driven technique simultaneously provides the platform with both excellent PS dispersity and leak‐proof properties due to the repulsion between the same‐charged molecules and the electrostatic attraction between different‐charged PS and silica channel walls, respectively. The as‐coated silica shell with an ultrathin thickness of 12±2?nm is delicately fabricated to facilitate ultrafast PS loading and efficient energy transfer from UCNP to PS. The outside surface of the silica shell is capped with hydrophilic β‐cyclodextrin, which not only enhances the dispersion of resulting nanoparticles in water but also plays a role of “gatekeeper”, blocking the pore opening and preventing PS leaking. The in vitro cellular lethality experiment demonstrates that RB molecules can be activated to effectively generate singlet oxygen and kill cancer cells upon 808?nm NIR light irradiation. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>抽象</ title> >基于中孔 - 二氧化硅涂覆的上变频纳米粒子（UCNP）的新型光动力治疗纳米膜（UCNP），静电驱动的超快光敏剂（PS）负载和808〜NM近红外线（NIR） - 灯触发能力。通过用氨基呈正质量充电中孔二氧化硅壳的内通道，可以在2？min中加载玫瑰孟加拉（RB）分子的带负电荷PS的定量剂量。此外，静电驱动技术同时为平台提供优异的PS分散性和防漏性能，由于同一带电分子与不同电荷的PS和二氧化硅通道壁之间的静电吸引之间的排斥。用超薄厚度为12±2·NM的涂层二氧化硅壳被精致地制造，以促进超快PS加载和从UCNP到PS的有效能量转移。二氧化硅壳的外表面用亲水性β-环糊精盖，其不仅增强了所得纳米颗粒在水中的分散体，而且还发挥着“门守”的作用，阻挡孔开口并防止PS泄漏。体外细胞致死性实验表明，可以激活RB分子，以有效地产生单线氧并杀死癌细胞在808℃下的光照照射。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16161/'>《Chemistry, an Asian journal》</a> <b style="margin: 0 2px;">|</b><span>2017年第17期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Han Renlu&option=202" target="_blank" rel="nofollow">Han Renlu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Junhui&option=202" target="_blank" rel="nofollow">Shi Junhui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Zongjun&option=202" target="_blank" rel="nofollow">Liu Zongjun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Hao&option=202" target="_blank" rel="nofollow">Wang Hao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang You&option=202" target="_blank" rel="nofollow">Wang You;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001 P.R. China;</p> <p>School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001 P.R. China;</p> <p>School of Chemical Engineering and TechnologyHarbin Institute of TechnologyHarbin 150001 P.R. China;</p> <p>School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001 P.R. China;</p> <p>School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001 P.R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=808?nm near infrared light&option=203" rel="nofollow">808?nm near infrared light;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mesoporous silica&option=203" rel="nofollow">mesoporous silica;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photodynamic therapy&option=203" rel="nofollow">photodynamic therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ultrafast photosensitizer loading&option=203" rel="nofollow">ultrafast photosensitizer loading;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=upconverting nanoparticles&option=203" rel="nofollow">upconverting nanoparticles;</a> </p> <div class="translation"> 机译：808？NM近红外光;中孔二氧化硅;光动力疗法;超速光敏剂负载;上变频纳米粒子; 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