A Promiscuous Cytochrome P450 Hydroxylates Aliphatic and Aromatic C?H Bonds of Aromatic 2,5‐Diketopiperazines

机译：一种混杂的细胞色素p450羟基族脂族和芳族C-H键的芳族2,5-二酮哌嗪

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Abstract > Cytochrome P450 enzymes generally functionalize inert C?H bonds, and thus, they are important biocatalysts for chemical synthesis. However, enzymes that catalyze both aliphatic and aromatic hydroxylation in the same biotransformation process have rarely been reported. A recent biochemical study demonstrated the P450 TxtC for the biosynthesis of herbicidal thaxtomins as the first example of this unique type of enzyme. Herein, the detailed characterization of substrate requirements and biocatalytic applications of TxtC are reported. The results reveal the importance of N‐methylation of the thaxtomin diketopiperazine (DKP) core on enzyme reactions and demonstrate the tolerance of the enzyme to modifications on the indole and phenyl moieties of its substrates. Furthermore, hydroxylated, methylated, aromatic DKPs are synthesized through a biocatalytic route comprising TxtC and the promiscuous N ‐methyltransferase Amir_4628; thus providing a basis for the broad application of this unique P450. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >细胞色素p450酶通常官能化惰性C'h键，因此它们是重要的生物催化剂化学合成。然而，很少报道催化在相同的生物转化过程中催化脂族和芳族羟基化的酶。最近的生化研究证明了除草剂的生物合成的P450 TXTC作为这种独特类型的酶的第一个例子。这里，报道了TXTC的底物要求和生物催化应用的详细表征。结果揭示了硫脲二酮哌嗪（DKP）核的N-甲基化对酶反应的重要性，并证明酶对其基材的吲哚和苯基部分的改性的耐受性。此外，通过包含TxtC和混合物的生物催化途径合成羟基化，甲基化，芳族DKP，并将其混杂的 n-甲基转移酶AMIR_4628合成。因此，为广泛应用这种独特的P450提供基础。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2019年第8期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jiang Guangde&option=202" target="_blank" rel="nofollow">Jiang Guangde;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yi&option=202" target="_blank" rel="nofollow">Zhang Yi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Powell Magan M.&option=202" target="_blank" rel="nofollow">Powell Magan M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hylton Sarah M.&option=202" target="_blank" rel="nofollow">Hylton Sarah M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiller Nicholas W.&option=202" target="_blank" rel="nofollow">Hiller Nicholas W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Loria Rosemary&option=202" target="_blank" rel="nofollow">Loria Rosemary;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Yousong&option=202" target="_blank" rel="nofollow">Ding Yousong;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> <p>Department of Plant PathologyUniversity of FloridaGainesville FL 32611 USA;</p> <p>Department of Medicinal ChemistryUniversity of FloridaGainesville FL 32610 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biocatalysis&option=203" rel="nofollow">biocatalysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cytochromes&option=203" rel="nofollow">cytochromes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=enzymes&option=203" rel="nofollow">enzymes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydroxylation&option=203" rel="nofollow">hydroxylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=structure–activity relationship&option=203" rel="nofollow">structure–activity relationship;</a> </p> <div class="translation"> 机译：生物催化;细胞学;酶;羟基化;结构 - 活动关系; 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