Sex-specific regulation of collagen I and III expression by 17-Estradiol in cardiac fibroblasts: role of estrogen receptors

摘要

Aims Sex differences in cardiac fibrosis point to the regulatory role of 17-Estradiol (E2) in cardiac fibroblasts (CF). We, therefore, asked whether male and female CF in rodent and human models are differentially susceptible to E2, and whether this is related to sex-specific activation of estrogen receptor alpha (ER) and beta (ER).