CARBOXYMETHYL CELLULOSE ESTERS AS STABILIZERS FOR HYDROPHOBIC DRUGS IN AQUEOUS MEDIUM

摘要

In the present study, amphiphilic polymers, carboxymethyl cellulose acetate (CMCA) and carboxymethyl cellulose acetate butyrate (CMCAB), with hydrophobic and hydrophilic moieties, were prepared from cellulose extracted from bagasse. The prepared amphiphilic celluloses were characterized by Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). These esters were investigated as stabilizers of sulfadiazine drug in water dispersion. The results showed that CMCAB had higher drug loading efficiency than CMCA.