LC3‐association with the parasitophorous vacuole membrane of        <i >Plasmodium bergheiPlasmodium berghei        liver stages follows a noncanonical autophagy pathway

Wacker Rahel; Eickel Nina; Schmuckli‐Maurer Jacqueline; Annoura Takeshi; Niklaus Livia; Khan Shahid M.; Guan Jun‐Lin; Heussler Volker T.

摘要

Summary > Eukaryotic cells can employ autophagy to defend themselves against invading pathogens. Upon infection by Plasmodium berghei sporozoites, the host hepatocyte targets the invader by labelling the parasitophorous vacuole membrane (PVM) with the autophagy marker protein LC3. Until now, it has not been clear whether LC3 recruitment to the PVM is mediated by fusion of autophagosomes or by direct incorporation. To distinguish between these possibilities, we knocked out genes that are essential for autophagosome formation and for direct LC3 incorporation into membranes. The CRISPR/Cas9 system was employed to generate host cell lines deficient for either FIP200, a member of the initiation complex for autophagosome formation, or ATG5 , responsible for LC3 lipidation and incorporation of LC3 into membranes. Infection of these knockout cell lines with P .? berghei sporozoites revealed that LC3 recruitment to the PVM indeed depends on functional ATG5 and the elongation machinery, but not on FIP200 and the initiation complex, suggesting a direct incorporation of LC3 into the PVM. Importantly, in P .? berghei ‐infected ATG5 ?/? host cells, lysosomes still accumulated at the PVM, indicating that the recruitment of lysosomes follows an LC3‐independent pathway. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”> <标题类型=“main”>摘要</ title> >真核细胞可以采用自噬用于防御入侵的病原体。在感染疟原虫porghei </ i>孢子子后，宿主肝细胞通过用自噬标志物蛋白Lc3标记寄生液泡膜（PVM）来靶向入侵者。到目前为止，目前尚不清楚LC3对PVM的招募是否通过融合自噬体或通过直接融合来介导。为了区分这些可能性，我们敲出了对自噬体形成和直接LC3掺入膜上至关重要的基因。使用CRISPR / CAS9系统以产生缺乏FIP200的宿主细胞系，对自噬体形成的初始复合物的成员，或负责LC3脂质的ATG5 <I>，并将LC3掺入膜中。用 p </ i>感染这些敲除细胞系。？ Berghei </ i>孢子液显示LC3对PVM的招募确实取决于功能性ATG5和伸长机械，但不在FIP200和起始复合物上，表明LC3直接掺入PVM。重要的是，在 p </ i>中。 Berghei </ i> -infected Atg5 </ i> α/α/ηs> </ sup>宿主细胞，溶酶体仍然积累在PVM，表明招募溶酶体遵循LC3无关的途径。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2017年第10期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wacker Rahel&option=202" target="_blank" rel="nofollow">Wacker Rahel;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eickel Nina&option=202" target="_blank" rel="nofollow">Eickel Nina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmuckli‐Maurer Jacqueline&option=202" target="_blank" rel="nofollow">Schmuckli‐Maurer Jacqueline;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Annoura Takeshi&option=202" target="_blank" rel="nofollow">Annoura Takeshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Niklaus Livia&option=202" target="_blank" rel="nofollow">Niklaus Livia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Khan Shahid M.&option=202" target="_blank" rel="nofollow">Khan Shahid M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guan Jun‐Lin&option=202" target="_blank" rel="nofollow">Guan Jun‐Lin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Heussler Volker T.&option=202" target="_blank" rel="nofollow">Heussler Volker T.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Institute of Cell BiologyUniversity of BernBern Switzerland;</p> <p>Institute of Cell BiologyUniversity of BernBern Switzerland;</p> <p>Institute of Cell BiologyUniversity of BernBern Switzerland;</p> <p>Department of ParasitologyNational Institute of Infectious Diseases (NIID)Tokyo Japan;</p> <p>Institute of Cell BiologyUniversity of BernBern Switzerland;</p> <p>Center of Infectious DiseasesLeiden University Medical CenterLeiden The Netherlands;</p> <p>Department of Cancer BiologyUniversity of Cincinnati College of MedicineCincinnati OH USA;</p> <p>Institute of Cell BiologyUniversity of BernBern Switzerland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032108.html">LC3‐association with the parasitophorous vacuole membrane of <i >Plasmodium bergheiPlasmodium berghei liver stages follows a noncanonical autophagy pathway</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wacker Rahel&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wacker Rahel,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eickel Nina&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Eickel Nina,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmuckli‐Maurer Jacqueline&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schmuckli‐Maurer Jacqueline,</a> <a href="/journal-foreign-15891/" target="_blank" rel="nofollow" class="tuijian_authcolor">Cellular microbiology .</a> <span>2017</span><span>,第10期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：LC3-与疟原虫Perghei的寄生液泡膜联合</ i> Perghei肝脏疟原虫阶段的疟原虫伴随着非甘露出的自噬途径</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204116979914.html">A Plasmodium Phospholipase Is Involved in Disruption of the Liver Stage Parasitophorous Vacuole Membrane</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paul-Christian Burda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Paul-Christian Burda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matthias A. Roelli&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Matthias A. Roelli,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marco Schaffner&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Marco Schaffner,</a> <a href="/journal-foreign-29521/" target="_blank" rel="nofollow" class="tuijian_authcolor">PLoS Pathogens .</a> <span>2015</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疟原虫磷脂酶参与肝阶段寄生虫液泡膜的破坏。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204116972977.html">A Plasmodium Phospholipase Is Involved in Disruption of the Liver Stage Parasitophorous Vacuole Membrane</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paul-Christian Burda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Paul-Christian Burda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matthias A. Roelli&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Matthias A. Roelli,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marco Schaffner&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Marco Schaffner,</a> <a href="/journal-foreign-29521/" target="_blank" rel="nofollow" class="tuijian_authcolor">PLoS Pathogens .</a> <span>2015</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疟原虫磷脂酶参与肝阶段寄生虫液泡膜的破坏。</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-255935_thesis/070509993962.html">Cloning of a Novel Plasmodium Yoelii Parasitophorous Vacuole Memebrane Gene</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=T. Sam-Yellowe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">T. Sam-Yellowe,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=T. Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">T. Wang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=J. Tao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">J. Tao,</a> <a href="/conference-foreign-255935/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Congress of Parasitology .</a> <span>2006</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：克隆一种新型疟原虫杨柳寄生液泡膜基因</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061140803.html">1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Natarajan, Ramya.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Natarajan, Ramya. </a> <span>2006</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_plos-clinical-trials_thesis/040002066350.html">Plasmodium berghei Δp52&p36 Parasites Develop Independent of a Parasitophorous Vacuole Membrane in Huh-7 Liver Cells</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ivo H. J. Ploemen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ivo H. J. Ploemen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huib J. Croes&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Huib J. Croes,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Geert-Jan J. van Gemert&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Geert-Jan J. van Gemert,</a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：伯氏疟原虫Δp52＆p36寄生虫独立于Huh-7肝细胞中的寄生虫液膜发展。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000115355714.html ">Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane.</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jacqueline Schmuckli-Maurer&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jacqueline Schmuckli-Maurer,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vera Reber&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Vera Reber,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rahel Wacker&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Rahel Wacker,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：将自噬蛋白倒置募集到伯氏疟原虫寄生泡液膜上。</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/020711368769.html">Primary Structure of a Lysine and Glutamate Rich Plasmodium Falciparum Antigen Located at the Merozoite Surface and in the Parasitophorous Vacuole.</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chulay, J. D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chulay, J. D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Lyon, J. A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Lyon, J. A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Wolff, R. H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Wolff, R. H.,</a> <span>1988</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：富含赖氨酸和谷氨酸的恶性疟原虫抗原的初级结构，位于裂殖子表面和寄生蜂体内。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130400560787.html">VIRUS-LIKE PARTICLES COMPRISING THE INNER MEMBRANE COMPLEX OF PLASMODIUM BERGHEI, AND VACCINE COMPOSITIONS USING THEREOF</a> <b>[P]</b> . <span> 外国专利：  KR102168661B1 </span> <span> . 2020-10-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含伯氏疟原虫内膜复合物的病毒样颗粒以及使用其的疫苗组合物 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130417519759.html">LSA-5 LIVER STAGE AND BLOOD STAGE ANTIGEN OF PLASMODIUM FALCIPARUM, IMMUNOGENIC COMPOSITION COMPRISING SAID ANTIGEN, AND VACCINES AGAINST MALARIA</a> <b>[P]</b> . <span> 外国专利：  CA2548792C </span> <span> . 2014-07-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：恶性疟原虫的LSA-5肝阶段和血液阶段抗原，包含所述抗原的免疫原性成分和抗疟疾疫苗 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130417951013.html">LSA-5 liver stage and blood stage antigen of <I>Plasmodium falciparum</I>, immunogenic composition comprising said antigen, and vaccines against malaria</a> <b>[P]</b> . <span> 外国专利：  US8765145B2 </span> <span> . 2014-07-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：恶性疟原虫的LSA-5肝和血阶段抗原，包含该抗原的免疫原性组合物和抗疟疾疫苗 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022032108','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704022032108down" data-source="7," data-out-id="j5oXDgYxwNTmQqxV8uV39+nui82opWWJK4D27+xGQWvr7xXY5wU6/ifyB3VX5boa," data-f-source-id="7" data-title="LC3‐association with the parasitophorous vacuole membrane of <i >Plasmodium bergheiPlasmodium berghei liver stages follows a noncanonical autophagy pathway" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="0704022032108" id="docid"> <input type="hidden" value="15891" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="LC3‐association with the parasitophorous vacuole membrane of <i >Plasmodium bergheiPlasmodium berghei liver stages follows a noncanonical autophagy pathway"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/page.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/reference.js?v=5.8.0"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.8.0"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>

LC3‐association with the parasitophorous vacuole membrane of Plasmodium bergheiPlasmodium berghei liver stages follows a noncanonical autophagy pathway

摘要