<fi >Mycobacterium tuberculosis</fi>Mycobacterium tuberculosis        Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin‐mediated signalling pathway

Zhang Yong; Li Jie; Li Bingxi; Wang Jing; Liu Cui Hua

摘要

Abstract > Establishment of infection by facultative intracellular pathogen <fi>Mycobacterium tuberculosis</fi> (Mtb) requires adherence to and internalisation by macrophages. However, the effector molecules exploited by Mtb for entry into macrophages remain to be fully understood. The mammalian cell entry (Mce) proteins play an essential role in facilitating the internalisation of mycobacteria into mammalian cells. Here, we characterized Mtb Mce3C as a new mycobacterial surface protein that could promote mycobacterial adhesion to and invasion of macrophages in an RGD motif‐dependent manner. We then further demonstrated that β2 integrin was required for Mce3C‐mediated cell entry. In addition, we found that binding of Mce3C recruited β2 integrin‐dependent signalling adaptors and induced local actin rearrangement at the site of mycobacterial invasion. By using specific antibodies and pharmacological inhibitors, we further demonstrated the involvement of Src‐family tyrosine kinases, spleen tyrosine kinase, Vav, Rho, and Rho‐associated kinase in Mce3C‐mediated mycobacterial invasion. Our results reveal a novel mechanism by which Mtb Mce3C exploits integrin‐mediated signalling cascade for Mce, providing potential targets for the development of therapies against Mtb infection. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>摘录</ title> >通过兼性细胞内病原体的感染<fi>结核分枝杆菌</ fi>（MTB）需要巨噬细胞遵守和内化。然而，MTB被用于进入巨噬细胞的效应分子仍然仍然得到完全理解。哺乳动物细胞进入（MCE）蛋白在促进分枝杆菌的内化成为哺乳动物细胞的基本作用。在这里，我们将MTB MCE3C作为一种新的分枝杆菌表面蛋白，可以以RGD基序的方式促进分枝杆菌粘附和侵袭巨噬细胞。然后，我们进一步证明了MCE3C介导的细胞入口需要β2整联蛋白。此外，我们发现MCE3C的结合募集了β2整合蛋白依赖性信号调整器，并在分枝杆菌侵袭部位诱导局部肌动蛋白重新排列。通过使用特异性抗体和药理抑制剂，我们进一步证明了SRC-Family酪氨酸激酶，脾酪氨酸激酶，VAV，RHO和RHO相关激酶在MCE3C介导的分枝杆菌侵袭中的参与。我们的结果揭示了一种新的机制，MTB MCE3C利用整合素介导的MCE的信号传导级联，提供针对MTB感染的疗法的潜在目标。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yong&option=202" target="_blank" rel="nofollow">Zhang Yong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jie&option=202" target="_blank" rel="nofollow">Li Jie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Bingxi&option=202" target="_blank" rel="nofollow">Li Bingxi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jing&option=202" target="_blank" rel="nofollow">Wang Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Cui Hua&option=202" target="_blank" rel="nofollow">Liu Cui Hua;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology Chinese Academy of SciencesBeijing China;</p> <p>CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology Chinese Academy of SciencesBeijing China;</p> <p>CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology Chinese Academy of SciencesBeijing China;</p> <p>CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology Chinese Academy of SciencesBeijing China;</p> <p>CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology Chinese Academy of SciencesBeijing China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microbial‐cell interaction&option=203" rel="nofollow">microbial‐cell interaction;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mycobacteria&option=203" rel="nofollow">mycobacteria;</a> </p> <div class="translation"> 机译：微生物细胞相互作用;分枝杆菌; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032082.html"><fi >Mycobacterium tuberculosis</fi>Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin‐mediated signalling pathway</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Yong,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li 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rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘忠泉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杜博平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杜博平</a> <span> <a href="/journal-cn-5570/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国防痨杂志 </a> </span> <span> . 2014</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-shihezi-university-natural-science_thesis/0201248706224.html">结核分枝杆菌感染小鼠肺泡巨噬细胞诱导结核分枝杆菌小分子热休克蛋白HSP16.3分泌表达模型的建立及鉴定</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董江涛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 董江涛</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐芳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,徐芳</a> <a 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=靳春燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 靳春燕</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120756286.html">一种用于促进分枝杆菌生长的结核分枝杆菌Rv1009蛋白及其应用</a> <b>[P]</b> . <span> 中国专利： CN101210045B </span> <span> . 2011.04.20</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120105404859.html">一种用于促进分枝杆菌生长的结核分枝杆菌Rv1009蛋白及其应用</a> <b>[P]</b> . <span> 中国专利： CN101210045A </span> <span> . 2008-07-02</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130424991867.html">COMPOSITION FOR SEPARATELY DETECTING MYCOBACTERIUM TUBERCULOSIS COMPLEX AND THE MYCOBACTERIUM GENUS, AND METHOD FOR SIMULTANEOUSLY DETECTING MYCOBACTERIUM TUBERCULOSIS AND THE MYCOBACTERIA GENUS BY A REAL-TIME MULTIPLEX POLYMERASE CHAIN REACTION USING 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Mycobacterium tuberculosisMycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin‐mediated signalling pathway

摘要