<fc >          <fi>Filifactor alocis</fi>        </fc>          <fi >Filifactor alocis</fi>Filifactor alocis                modulates human neutrophil antimicrobial functional responses

Edmisson Jacob S.; Tian Shifu; Armstrong Cortney L.; Vashishta Aruna; Klaes Christopher K.; Miralda Irina; Jimenez‐Flores Emeri; Le Junyi; Wang Qian; Lamont Richard J.; Uriarte Silvia M.

摘要

Abstract > <fi>Filifactor alocis</fi> is a newly appreciated pathogen in periodontal diseases. Neutrophils are the predominant innate immune cell in the gingival crevice. In this study, we examined modulation of human neutrophil antimicrobial functions by <fi>F.?alocis</fi> . Both non‐opsonised and serum‐opsonised <fi>F.?alocis</fi> were engulfed by neutrophils but were not efficiently eliminated. Challenge of neutrophils with either non‐opsonised or serum‐opsonised <fi>F.?alocis</fi> induced a minimal intracellular as well as extracellular respiratory burst response compared to opsonised <fc> <fi>Staphylococcus aureus</fi> </fc> and fMLF, respectively. However, pretreatment or simultaneous challenge of neutrophils with <fi>F.?alocis</fi> did not affect the subsequent oxidative response to a particulate stimulus, suggesting that the inability to trigger the respiratory response was only localised to <fi>F.?alocis</fi> phagosomes. In addition, although neutrophils engulfed live or heat‐killed <fi>F.?alocis</fi> with the same efficiency, heat‐killed <fi>F.?alocis</fi> elicited a higher intracellular respiratory burst response compared to viable organisms, along with decreased surface expression of CD35, a marker of secretory vesicles. <fi>F.?alocis</fi> phagosomes remained immature by delayed and reduced recruitment of specific and azurophil granules, respectively. These results suggest that <fi>F.?alocis</fi> withstands neutrophil antimicrobial responses by preventing intracellular ROS production, along with specific and azurophil granule recruitment to the bacterial phagosome. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > <fi> flifactor alocis </ fi>是一种新的牙周病病原体。中性粒细胞是牙龈缝隙中的主要先天免疫细胞。在这项研究中，我们通过<fi> f.?alocis </ fi>检查了人性化粒细胞抗微生物功能的调节。非opsonise和血清opsonisize <fi> f.?alocis </ fi>被嗜中性粒细胞吞噬，但未有效地消除。与非opsonise或血清opmsonise <fi> f的核心症患者与Opsonisize <Fc> <fi>金黄色葡萄球菌相比，细胞内的细胞内以及细胞外呼吸爆发响应诱导。 / FC>和FMLF分别。然而，用<fi> f的预处理或同时挑战与<fi> f.?alocis </ fi>不影响随后对颗粒刺激的氧化反应，表明无法触发呼吸反应仅局部局限于<fi> f。？alocis </ fi>吞噬物质。此外，虽然中性粒细胞吞噬或热杀死的<FI> F.?ALOCIS </ FI>具有相同的效率，热杀死的<FI> F.?ALOCIS（相比）引发了更高的细胞内呼吸爆发响应活性生物，以及CD35的表面表达减少，分泌囊泡的标志物。 <Fi> F.?Alocis </ Fi>吞噬物质通过延迟和减少特异性和硫酸硫酸颗粒的募集而保持不成熟。这些结果表明，通过预防细胞内ROS产生，与细菌吞噬体募集的特异性和硫酸硫醇颗粒募集，致反应中性粒细胞抗菌反应。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology 》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b> <span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Edmisson Jacob S.&option=202" target="_blank" rel="nofollow">Edmisson Jacob S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Shifu&option=202" target="_blank" rel="nofollow">Tian Shifu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Armstrong Cortney L.&option=202" target="_blank" rel="nofollow">Armstrong Cortney L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vashishta Aruna&option=202" target="_blank" rel="nofollow">Vashishta Aruna;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klaes Christopher K.&option=202" target="_blank" rel="nofollow">Klaes Christopher K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miralda Irina&option=202" target="_blank" rel="nofollow">Miralda Irina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jimenez‐Flores Emeri&option=202" target="_blank" rel="nofollow">Jimenez‐Flores Emeri;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Le Junyi&option=202" target="_blank" rel="nofollow">Le Junyi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Qian&option=202" target="_blank" rel="nofollow">Wang Qian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lamont Richard J.&option=202" target="_blank" rel="nofollow">Lamont Richard J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Uriarte Silvia M.&option=202" target="_blank" rel="nofollow">Uriarte Silvia M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Microbiology &</p> <p>Immunology School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Microbiology &</p> <p>Immunology School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Oral Immunology and Infectious Diseases School of DentistryUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Oral Immunology and Infectious Diseases School of DentistryUniversity of LouisvilleLouisville KY USA;</p> <p>Department of Medicine School of MedicineUniversity of LouisvilleLouisville KY USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=granule exocytosis&option=203" rel="nofollow">granule exocytosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=human neutrophils&option=203" rel="nofollow">human neutrophils;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neutrophil killing mechanisms&option=203" rel="nofollow">neutrophil killing mechanisms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oral pathogens&option=203" rel="nofollow">oral pathogens;</a> </p> <div class="translation"> 机译：颗粒外毒性;人性化学粒细胞;中性粒细胞杀伤机制;口服病原体; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022031906.html"><fc > <fi>Filifactor alocis</fi> </fc> <fi >Filifactor alocis</fi>Filifactor alocis modulates human neutrophil antimicrobial functional responses</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Edmisson Jacob S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Edmisson Jacob S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Shifu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tian Shifu,</a> <a 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target="_blank" rel="nofollow" class="tuijian_authcolor"> . 电子技术与软件工程 </a> </span> <span> . 2017</span><span> ,第018期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_computer-systems-applications_thesis/0201241521305.html">基于K-Means和FCM的增强型Wi-Fi指纹定位策略</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=单文杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,单文杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨丰玉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨丰玉</a> <span> <a href="/journal-cn-8907/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 计算机系统应用 </a> </span> <span> . 2017</span><span> ,第005期</span> </span> </div> </li> <li> <div> <b>6. 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭嘉玉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郭嘉玉</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204321322.html">一种基于广电HFC网络的Wi-Fi实名认证方法</a> <b>[P]</b> . <span> 中国专利： CN108173848B </span> <span> . 2021.04.02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202960866.html">使用NFC的WI-FI直连服务方法及其设备</a> <b>[P]</b> . <span> 中国专利： CN104956761B </span> <span> . 2018.08.10</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130402830154.html">WI-FI DIRECT SERVICE METHOD USING NFC AND DEVICE THEREFOR</a> <b>[P]</b> . <span> 外国专利：  EP2914047B1 </span> <span> . 2020-04-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用NFC的Wi-Fi直接服务方法及其装置 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130408697130.html">MOBILE TERMINAL LOCATION INFORMATION INTERWORKING TRANSMITTING METHOD THOUGH NFC-BASED WI-FI AUTOMATIC CONNECTION SERVICE</a> <b>[P]</b> . <span> 外国专利：  KR20170070955A </span> <span> . 2017-06-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于NFC的Wi-Fi自动连接服务的移动终端位置信息交互传输方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130410020267.html">System using NFC, Bluetooth, and/or Wi-Fi Technologies for Making a Quick Connection between a Smart Mobile Electronic Device and Audio Speakers, with an Optional Video Display System</a> <b>[P]</b> . <span> 外国专利：  US2017180915A1 </span> <span> . 2017-06-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用NFC，蓝牙和/或Wi-Fi技术的系统，用于在智能移动电子设备和音频扬声器之间进行快速连接，并带有可选的视频显示系统 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022031906','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p 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Filifactor alocis Filifactor alocisFilifactor alocis modulates human neutrophil antimicrobial functional responses

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