Infection by        <fi >Brucella melitensis</fi>Brucella melitensis        or        <fi >Brucella papionis</fi>Brucella papionis        modifies essential physiological functions of human trophoblasts

García‐Méndez Karellen B.; Hielpos Soledad M.; Soler‐Llorens Pedro F.; Arce‐Gorvel Vilma; Hale Christine; Gorvel Jean‐Pierre; OCallaghan David; Keriel Anne

摘要

Abstract > Brucellosis is a zoonosis caused by bacteria of the Brucella genus. In ruminants, brucellosis causes abortion, followed by chronic infection and secretion of bacteria in milk. In humans, it usually presents as flu‐like symptoms, with serious complications if untreated. Epidemiological studies have only recently established that brucellosis can also cause pregnancy complications in women, but the pathogenic mechanisms are unknown. Pioneering studies in ruminants showed that Brucella infect trophoblasts and then colonise the placenta where they grow to high density. A recent study showed that the main zoonotic Brucella species can infect human cytotrophoblasts (CTB) and extravillous trophoblasts (EVT). In this work, we show that Brucella papionis (associated with stillbirth in primates) also infects human trophoblasts. However, it replicates actively in CTB, whereas its replication is very restricted within EVT. We also observed alteration of several trophoblastic functions upon infection by B .? papionis or Brucella melitensis (the most prevalent species in human brucellosis). Infection altered the production of hormones, the ability of CTB to form syncytiotrophoblasts, and the invasion capacity of EVT. We also found that infection can spread between different types of trophoblasts. These findings constitute a new step in understanding how Brucella infection causes adverse pregnancy outcomes. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> > Brucellosis是一种由细菌引起的 Brucella </ i>属的子宫。在反刍动物中，布鲁氏菌病导致流产，然后是慢性感染和牛奶细菌的分泌。在人类中，它通常呈现为流感样症状，如果未经处理，则具有严重的并发症。流行病学研究最近只确定了脆弱性也可能导致女性的妊娠并发症，但致病机制是未知的。反刍动物的开拓性研究表明，布鲁氏菌（Brucella）</ i>感染滋养细胞，然后在它们生长到高密度的胎盘中殖民。最近的一项研究表明，主要的动物质 Brucella </ i>物种可以感染人胞细胞培素（CTB）和外形滋养细胞（EVT）。在这项工作中，我们展示了 Brucella papionis（与激发物中的死产相关）也感染人滋养细胞。然而，它在CTB中积极复制，而其复制在EVT中非常受限制。我们还观察到通过 B </ i>感染的几种滋养细胞功能的改变。？ Papionis </ i>或 Brucella melitensis（人体安全性最普遍的物种）。感染改变了激素的产生，CTB能够形成合胞生殖细胞，以及EVT的侵袭能力。我们还发现感染可以在不同类型的滋养板之间传播。这些发现构成了解 Brucella </ i>感染引起不良妊娠结果的新步骤。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第7期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=García‐Méndez Karellen B.&option=202" target="_blank" rel="nofollow">García‐Méndez Karellen B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hielpos Soledad M.&option=202" target="_blank" rel="nofollow">Hielpos Soledad M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Soler‐Llorens Pedro F.&option=202" target="_blank" rel="nofollow">Soler‐Llorens Pedro F.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arce‐Gorvel Vilma&option=202" target="_blank" rel="nofollow">Arce‐Gorvel Vilma;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hale Christine&option=202" target="_blank" rel="nofollow">Hale Christine;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gorvel Jean‐Pierre&option=202" target="_blank" rel="nofollow">Gorvel Jean‐Pierre;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OCallaghan David&option=202" target="_blank" rel="nofollow">OCallaghan David;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keriel Anne&option=202" target="_blank" rel="nofollow">Keriel Anne;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>VBMI INSERMUniversité de MontpellierN?mes France;</p> <p>VBMI INSERMUniversité de MontpellierN?mes France;</p> <p>VBMI INSERMUniversité de MontpellierN?mes France;</p> <p>CIML INSERM CNRSUniversité Aix‐MarseilleMarseille France;</p> <p>Microbial PathogenesisWellcome Trust Sanger InstituteHinxton UK;</p> <p>CIML INSERM CNRSUniversité Aix‐MarseilleMarseille France;</p> <p>VBMI INSERMUniversité de MontpellierN?mes France;</p> <p>VBMI INSERMUniversité de MontpellierN?mes France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=abortion&option=203" rel="nofollow">abortion;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brucella melitensis&option=203" rel="nofollow">Brucella melitensis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brucella papionis&option=203" rel="nofollow">Brucella papionis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brucellosis&option=203" rel="nofollow">brucellosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CD98hc&option=203" rel="nofollow">CD98hc;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=placenta&option=203" rel="nofollow">placenta;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=trophoblast&option=203" rel="nofollow">trophoblast;</a> </p> <div class="translation"> 机译：堕胎;Brucella melitensis;Brucella Papionis;布鲁克枯;CD98HC;胎盘;滋养品; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_asia-pacific-tropical-medicine-journal-english_thesis/0201254095764.html">Simultaneous detection and differentiates of Brucella abortus and Brucella melitensis by combinatorial PCR</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reza Mirnejad&option=202" target="_blank" rel="nofollow" class="tuijian_auth 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Nurrul Shaqinah Nasruddin</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mazlina Mazlan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Mazlina Mazlan</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mohd Zamri Saad&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Mohd Zamri Saad</a> <span> <a href="/journal-cn-56403/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 病理学期刊（英文） </a> </span> <span> . 2014</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201294934435.html">iBrucella melitensis/iDiffers from iB. suis/iin Growth and Urease Activity iIn-Vitro/i, and Infectivity in Fisher-344 Rats iIn-Vivo/i</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aloka B. Bandara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Aloka B. Bandara</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stephen M. Boyle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Stephen M. Boyle</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Araceli Contreras-Rodriguez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Araceli Contreras-Rodriguez</a> <span> <a href="/journal-cn-56212/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 传染病进展（英文） </a> </span> <span> . 2013</span><span>,第1期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-sound-technology_thesis/0201295582135.html">KIT THAT CHANGED THE Hi-Fi WORLD改变Hi-Fi世界的铭器（上）</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯凌（编译）&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 冯凌（编译）</a> <span> <a href="/journal-cn-8853/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 现代音响技术 </a> </span> <span> . 2007</span><span>,第3期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312374212.html">FUNCTIONAL STUDY OF SMALL NOn-CODING RNA ABCR1 OF BRUCELLA MELITENSIS</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=WAQAS AHMED&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . WAQAS AHMED</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120110512161.html">将WI-FI用作人类控制接口</a> <b>[P]</b> . <span> 中国专利： CN108027661A </span> <span> . 2018-05-11</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130459939126.html">STRAIN OF BACTERIUM BRUCELLA MELITENSIS BIOVARA I USED FOR PREPARING OF POLYVALENT HYPERIMMUNE SERUM TO BRUCELLAS</a> <b>[P]</b> . <span> 外国专利：  RU2005781C1 </span> <span> . 1994-01-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于制备布鲁氏菌多价超免疫血清的产布鲁氏菌菌株 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130400495647.html">METHOD OF GENETIC INDEL-TYPING OF STRAINS OF BRUCELLA MELITENSIS</a> <b>[P]</b> . <span> 外国专利：  RU2732425C1 </span> <span> . 2020-09-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：布鲁氏菌增生菌株的基因型分型方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130423110165.html"><I>Brucella melitensis </I>mutants and methods</a> <b>[P]</b> . <span> 外国专利：  US8075879B2 </span> <span> . 2011-12-13</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：<I>布鲁氏菌</ I>突变体和方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div 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Infection by Brucella melitensisBrucella melitensis or Brucella papionisBrucella papionis modifies essential physiological functions of human trophoblasts

摘要