Ollier's disease: cytological findings

摘要

Ollier's disease is a rare, non-hereditary skeletal disorder characterized by a multifocal intra medullary proliferation of hypercellular cartilage. The lesions have a tendency to be metaphyseal and are sometimes eccentrically placed, with predominant unilateral involvement of the appendicular'skeleton.1 The clinical manifestation typically appears during childhood and the extent of skeletal involvement is variable from case to case. At one end of the spectrum are cases in which there is limited involvement of one bone and at the other end are cases with massive involvement of multiple bones and severe deformities. Although Ollier's disease has a predilection for the appendicular skeleton, in more severe forms the trunk bones can also be involved. The short tubular bones of hand are the commonest site, the pelvis being the most frequently involved of the trunk bones. Typically, the vertebral column or craniofacial bones are not affected.1'2 The most common symptom is slowly increasing swelling of the fingers. Radiologically the lesions have a tendency to be metaphyseal and diaphyseal, showing translucency with punctuate calcification which is typical of the radiographic appearance of cartilaginous matrix. The morphology of lesions in Ollier's disease is somewhat similar to that of solitary enchondroma. In general, the lesions are more cellular and less calcined than most typical solitary enchondromas. The cartilage cells are larger and double nucleated cells are also present.