Multiple Autoantibodies against Cardiovascular Receptors as Biomarkers in Hypertensive Heart Disease

摘要

Objectives: The pathogenesis of hypertensive heart disease (HHD) remains unclear, which might include autoimmunity. The aim of the present study was to determine whether a relationship exists between the presence of autoantibodies against beta 1, beta 2, alpha 1 adrenoreceptors, M-2-muscarinic receptors, angiotensin II type1 receptors and HHD. Methods: In the present study, 44 patients diagnosed with HHD, 36 patients with hypertension, and 40 controls were also enrolled. The measurement of these 5 autoantibodies was performed by enzyme-linked immunosorbent assay. Results: The frequencies of autoantibodies against beta 1, beta 2, alpha 1 adrenoreceptors, autoantibodies against M-2-muscarinic receptors and autoantibodies against angiotensin II type1 receptors were significantly higher in patients with HHD, when compared to patients with hypertension and normal controls (all p < 0.001). In addition, the titers of these 5 autoantibodies significantly increased in patients with HHD. Patients who were positive for all 5 autoantibodies had larger left ventricular end-diastolic diameter (60.5 +/- 4.9 vs. 57.8 +/- 5.0 vs. 52.5 +/- 5.3 mm) and worse left ventricular ejection fraction (45.0 +/- 11.0 vs. 56.6 +/- 10.4 vs. 57.8 +/- 5.3%), when compared to patients not positive for all the 5 autoantibodies and patients negative for all the 5 autoantibodies (chi(2) = 9.524, p = 0.009 and chi(2) = 7.689, p = 0.021). Furthermore, a significant positive correlation was observed between each 2 autoantibodies of these 5 autoantibodies (all p < 0.001). Conclusion: Multiple autoantibodies of cardiovascular receptors may be involved in the pathogenesis and may be predictive factors of HHD. (c) 2019 S. Karger AG, Basel