Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

Boehmer Anne C.; Hecker Julian; Schroeder Julia; Gharahkhani Puya; May Andrea; Gerges Christian; Anders Mario; Becker Jessica; Hess Timo; Kreuser Nicole; Thieme Rene; Noder Tania; Venerito Marino; Veits Lothar; Schmidt Thomas; Fuchs Claudia; Izbicki Jakob R.; Hoelscher Arnulf H.; Dietrich Arne; Moulla Yusef; Lyros Orestis; Lang Hauke; Lorenz Dietmar; Schumacher Brigitte; Mayershofer Rupert; Vashist Yogesh; Ott Katja; Vieth Michael; Meismueller Josef; Moebus Susanne; Knapp Michael; Neuhaus Horst; Roesch Thomas; Ell Christian; Noethen Markus M.; Whiteman David C.; Tomlinson Ian; Jankowski Janusz; Fitzgerald Rebecca C.; Palles Claire; Vaughan Thomas L.; Gockel Ines; Thrift Aaron P.; Fier Heide; Schumacher Johannes

首页> 外文期刊>Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research >Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

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Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

机译：与肥胖相关性状和Barrett的食管/腺癌的共同遗传病程：基因组 - 范围内的协会研究见解

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Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barrett's esophagus (BE). Research suggests that individuals with high genetic risk to obesity have a higher BE/EA risk. To facilitate understanding of biological factors that lead to progression from BE to EA, the present study investigated the shared genetic background of BE/EA and obesity-related traits.

机译：背景：肥胖是食管腺癌（EA）的主要危险因素及其前体巴雷特食管（BE）。研究表明，对肥胖的遗传风险高的个体具有更高的BE / EA风险。为了促进对从ea到ea导致进展的生物因素的理解，本研究调查了Be / EA和肥胖相关性状的共享遗传背景。

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《Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research》 |2020年第2期|共7页
作者
Boehmer Anne C.; Hecker Julian; Schroeder Julia; Gharahkhani Puya; May Andrea; Gerges Christian; Anders Mario; Becker Jessica; Hess Timo; Kreuser Nicole; Thieme Rene; Noder Tania; Venerito Marino; Veits Lothar; Schmidt Thomas; Fuchs Claudia; Izbicki Jakob R.; Hoelscher Arnulf H.; Dietrich Arne; Moulla Yusef; Lyros Orestis; Lang Hauke; Lorenz Dietmar; Schumacher Brigitte; Mayershofer Rupert; Vashist Yogesh; Ott Katja; Vieth Michael; Meismueller Josef; Moebus Susanne; Knapp Michael; Neuhaus Horst; Roesch Thomas; Ell Christian; Noethen Markus M.; Whiteman David C.; Tomlinson Ian; Jankowski Janusz; Fitzgerald Rebecca C.; Palles Claire; Vaughan Thomas L.; Gockel Ines; Thrift Aaron P.; Fier Heide; Schumacher Johannes;
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作者单位

Univ Bonn Inst Human Genet Venusberg Campus 1 D-53111 Bonn Germany;

Harvard TH Chan Sch Publ Hlth Dept Biostat Boston MA USA;

Univ Bonn Inst Human Genet Venusberg Campus 1 D-53111 Bonn Germany;

QIMR Berghofer Med Res Inst Stat Genet Brisbane Qld Australia;

Sana Klinikum Dept Med 2 Offenbach Germany;

Evangel Krankenhaus Dept Internal Med 2 Dusseldorf Germany;

Univ Hosp Hamburg Eppendorf Dept Interdisciplinary Endoscopy Hamburg Germany;

Univ Bonn Inst Human Genet Venusberg Campus 1 D-53111 Bonn Germany;

Univ Hosp Marburg Ctr Human Genet Marburg Germany;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Univ Hosp Hamburg Eppendorf Dept Interdisciplinary Endoscopy Hamburg Germany;

Otto von Guericke Univ Hosp Dept Gastroenterol Hepatol &

Infect Dis Magdeburg Germany;

Klinikum Bayreuth Inst Pathol Bayreuth Germany;

Heidelberg Univ Dept Gen Visceral &

Transplantat Surg Heidelberg Germany;

Univ Cologne Dept Gen Visceral &

Canc Surg Cologne Germany;

Univ Hamburg Univ Med Ctr Hamburg Eppendorf Dept Gen Visceral &

Thorac Surg Hamburg Germany;

Univ Cologne Dept Gen Visceral &

Canc Surg Cologne Germany;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Johannes Gutenberg Univ Mainz Univ Med Ctr Dept Gen Visceral &

Transplant Surg Mainz Germany;

Klinikum Darmstadt Dept Gen Visceral &

Thorac Surg Darmstadt Germany;

Elisabeth Hosp Dept Internal Med &

Gastroenterol Essen Germany;

Gastroenterol Burgweiher Bonn Germany;

Univ Hamburg Univ Med Ctr Hamburg Eppendorf Dept Gen Visceral &

Thorac Surg Hamburg Germany;

Heidelberg Univ Dept Gen Visceral &

Transplantat Surg Heidelberg Germany;

Klinikum Bayreuth Inst Pathol Bayreuth Germany;

Gastroenterol Gemeinschaftspraxis Koblenz Germany;

Univ Essen Gesamthsch Inst Med Informat Biometry &

Epidemiol Ctr Urban Epidemiol Essen Germany;

Univ Bonn Inst Med Biometry Informat &

Epidemiol Bonn Germany;

Evangel Krankenhaus Dept Internal Med 2 Dusseldorf Germany;

Univ Hosp Hamburg Eppendorf Dept Interdisciplinary Endoscopy Hamburg Germany;

Sana Klinikum Dept Med 2 Offenbach Germany;

Univ Bonn Inst Human Genet Venusberg Campus 1 D-53111 Bonn Germany;

QIMR Berghofer Med Res Inst Canc Control Brisbane Qld Australia;

Univ Oxford Wellcome Trust Ctr Human Genet Oxford England;

Univ Cent Lancashire Westlakes Sci &

Technol Pk Moor Row England;

Hutchison MRC Res Ctr MRC Canc Unit Cambridge England;

Univ Oxford Wellcome Trust Ctr Human Genet Oxford England;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Univ Hosp Leipzig Dept Visceral Transplant Thorac &

Vasc Surg Leipzig Germany;

Baylor Coll Med Dan L Duncan Comprehens Canc Ctr Houston TX 77030 USA;

Harvard TH Chan Sch Publ Hlth Dept Biostat Boston MA USA;

Univ Bonn Inst Human Genet Venusberg Campus 1 D-53111 Bonn Germany;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies [J] . Boehmer Anne C., Hecker Julian, Schroeder Julia, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2020,第2期

机译：与肥胖相关性状和Barrett的食管/腺癌的共同遗传病程：基因组 - 范围内的协会研究见解
2. Common Variants Confer Susceptibility to Barrett's Esophagus: Insights from the First Genome-Wide Association Studies [J] . Claire Palles, John M. Findlay, Ian Tomlinson Advances in Experimental Medicine and Biology . 2016,第Null期

机译：常见变异赋予Barrett食管易感性：第一批全基因组关联研究的见解
3. Shared genetic etiology of hypertension and stroke: evidence from bioinformatics analysis of genome-wide association studies. [J] . L D Ji, S P Hu, J Y Li, Journal of human hypertension . 2018,第1期

机译：高血压和中风的共同遗传病因：来自生物信息学分析的基因组关联研究的证据。
4. Genetic Etiology of Tumors with Genome-Wide Association Study [C] . Ming Zheng, Mugui Zhuo International Conference on Education, Management, Information and Mechanical Engineering . 2017

机译：基因组关联研究肿瘤的遗传病程
5. Signal Transduction in Barrett's Esophagus and Esophageal Adenocarcinoma [D] . Narendran, Nirushan Harushikesh. 2018

机译：巴雷特食管和食道腺癌中的信号转导
6. Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits [O] . Tugce Karaderi, Alexander W. Drong, Cecilia M. Lindgren -1

机译：从肥胖相关性状的全基因组关联研究中洞悉2型糖尿病的遗传易感性
7. Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies [O] . Anne C. Böhmer, Julian Hecker, Julia Schröder, 2019

机译：与肥胖相关性状和Barrett的食管/腺癌的共同遗传病程：基因组 - 范围内的协会研究见解

Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

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