Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade

Mikyung Park; Ho Jeong Kwon; Seong Hwan Kim

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Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade

机译：Homoharringtonine通过Wnt /β-catenin信号传导级联的下调诱导人结肠直肠癌Hct116细胞中的细胞凋亡

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摘要

Many tumors are relevant to the abnormal up-regulated transcriptional activity of P-catenin that interacts with T-cell factor (TCF) and lymphoid-enhancing factor (LEF) to induce the transcription of Wnt/β-catenin-response genes. Since β-catenin is commonly dysregulated in colon cancer, targeting of β-catenin has been considered for therapeutic purposes to treat colon cancer.

机译：许多肿瘤与P-Catenin的异常上调转录活性相关，其与T细胞因子（TCF）和淋巴增强因子（LEF）相互作用以诱导Wnt /β-连环蛋白响应基因的转录。由于β-连环蛋白通常在结肠癌中常见，因此已经考虑了β-catenin的靶向治疗结肠癌的治疗目的。

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《Bulletin of the Korean Chemical Society》 |2019年第2期|共4页
作者
Mikyung Park; Ho Jeong Kwon; Seong Hwan Kim;
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作者单位

Innovative Target Research Center Bio &

Drug Discovery Division Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea;

Chemical Genomics GRL Department of Biotechnology Yonsei University College of Life Science &

Biotechnology Seoul 03722 Republic of Korea;

Innovative Target Research Center Bio &

Drug Discovery Division Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Homoharringtonine; Wnt; β-Catenin; Porcupine; Colon cancer;

机译：homoharringtonine;wnt;β-catenin;豪猪;结肠癌;

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1. Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade [J] . Mikyung Park, Ho Jeong Kwon, Seong Hwan Kim Bulletin of the Korean Chemical Society . 2019,第2期

机译：Homoharringtonine通过Wnt /β-catenin信号传导级联的下调诱导人结肠直肠癌Hct116细胞中的细胞凋亡
2. Water extract of brewers’ rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers’ rice-treated rats with azoxymethane-induced colon carcinogenesis [J] . Bee Ling Tan, Mohd Esa Norhaizan, Ky Huynh, BMC Complementary and Alternative Medicine . 2015,第1期

机译：啤酒大米的水提取物通过激活caspase-3和caspase-8诱导人结肠直肠癌细胞凋亡，并下调啤酒大米处理的大鼠中由乙氧基甲烷诱导的结肠癌发生的Wnt /β-catenin下游信号通路。
3. Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells [J] . Hidayat Ahmad Fadhlurrahman Ahmad, Chan Chim Kei, Mohamad Jamaludin, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：Dioscorea Bulbifera通过抑制ERK 1/2和HCT116人结肠癌细胞中的JNK信号通路的激活来诱导细胞凋亡
4. Sensitization of human colorectal cancer cells to paclitaxel- induced apoptosis by inhibition of MEK/ERK pathway is caspase-4 dependent [C] . NIZAR M. MHAIDAT, SAIED A. JARADAT, ABDULHAMEED GHABKARI Recent researches in modern medicine . 2011

机译：通过抑制MEK / ERK途径使大肠癌细胞对紫杉醇诱导的细胞凋亡的敏感性取决于caspase-4
5. Cytokine-induced Wnt/beta-catenin Signaling in Intestinal Stem Cells in Inflammatory Bowel Disease. [D] . Ryu, Hyunji. 2014

机译：炎性肠病中肠干细胞中细胞因子诱导的Wnt /β-catenin信号转导。
6. Obatoclax a Pan-BCL-2 Inhibitor Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling [O] . Chi-Hung R. Or, Chiao-Wen Huang, Ching-Chin Chang, 2020

机译：Obatoclax是Pan-Bcl-2抑制剂下调Survivin通过抑制Wnt /β-catenin信号传导来诱导人结肠癌细胞的细胞凋亡
7. Water extract of brewers’ rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers’ rice-treated rats with azoxymethane-induced colon carcinogenesis [O] . Bee Ling Tan, Mohd Esa Norhaizan, Ky Huynh, 2015

机译：啤酒大米的水提取物通过激活caspase-3和caspase-8诱导人大肠癌细胞凋亡，并下调啤酒酿造的稻谷大鼠用乙氧基甲烷诱导的结肠癌发生过程中的Wnt /β-catenin下游信号通路。

Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade

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