Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

摘要

Aims: The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA (TM)) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes. Methods: Data were obtained for solute clearance and sieving coefficients of vitamin B-12 and a range of polydisperse dextrans using ATA (TM) SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models. Results: The ATA (TM) had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA (TM) membrane providing much higher diffusive transport rates (and thus higher solute clearance). Conclusions: These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA (TM) dialyzers. (C) 2017 S. Karger AG, Basel