Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells

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Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells

机译：调查和开发，冻干和制定的CHO细胞产生的冻干和配制的重组人因子IX

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Objectives To develop a recombinant human factor IX (rFIX) formulation equivalent to commercially available products in terms of cake appearance, residual moisture, proportion of soluble aggregates and activity maintenance for 3 months at 4-8 degrees C.

机译：目的是开发一种重组人体因子IX（RFIX）配方，其等同于商业上可获得的产品，在蛋糕外观，残余水分，可溶性聚集体比例和活性维持在4-8℃下3个月。

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《Biotechnology Letters》 |2017年第8期|共12页
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正文语种 eng
中图分类分子生物学;
关键词
Excipients; Formulation; Freeze-drying; Lyophilization; Recombinant factor IX; Stability study;

机译：赋形剂;配方;冷冻干燥;冻干;重组因子IX;稳定性研究;

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专利

1. Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells [J] . Biotechnology Letters . 2017,第8期

机译：调查和开发，冻干和制定的CHO细胞产生的冻干和配制的重组人因子IX
2. Producing and secreting human factor IX with high efficiency by murine primary and C2C12 muscle cells carrying human factor IX gene [J] . Wang Jianmin, He Jun, Kurachi K Journal of Medical Colleges of PLA . 1999,第3期

机译：通过携带人IX因子基因的鼠原代和C2C12肌细胞高效生产和分泌人IX因子
3. Producing and secreting human factor IX with high efficiency by murine primary and C2C12 muscle cells carrying human factor IX gene [J] . 王健民, 何军中国人民解放军军医大学学报：英文版 . 1999,第003期

机译：通过携带人为因子IX基因的鼠初级和C2C12肌细胞高效生产和分泌人为因子IX
4. The Effects of Medium Supplement on High-Level Production of Recombinant Human Factor IX in CHO Cell [C] . InHwan Lim, Jung-Seob Kim, Guehwa Lee, European Society of Animal Cell Technology . 2010

机译：中等补编对CHO细胞重组人体因子IX高级别生产的影响
5. The development of a cell culture process for the production of recombinant human beta inteferon (β-IFN) from a transfected Chinese hamster ovary (CHO) cell line [D] . Rodriguez, Jose Fernando 2008

机译：从转染的中国仓鼠卵巢（CHO）细胞系生产重组人β干扰素（β-IFN）的细胞培养方法的开发
6. Recombinant Human Factor IX Produced from Transgenic Porcine Milk [O] . Meng-Hwan Lee, Yin-Shen Lin, Ching-Fu Tu, -1

机译：从转基因猪乳中产生的重组人因子IX
7. Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells [O] . Almeida, Aline G., Pinto, Rodrigo C. V., Smales, C. Mark, 2017

机译：从CHO细胞生产的冻干和配制的重组人因子IX的研究和开发

Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells

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