Effects of xylitol dehydrogenase ( <i xmlns='http://www.wiley.com/namespaces/wiley'>XYL2XYL2 ) on xylose fermentation by engineered <i xmlns='http://www.wiley.com/namespaces/wiley'>Candida glycerinogenesCandida glycerinogenes

Zong Hong; Zhang Cheng; Zhuge Bin; Lu Xinyao; Fang Huiying; Sun Jin

摘要

Abstract > Efficient bioconversion of <sc>d</sc> ‐xylose into various biochemicals is critical for lignocelluloses application. Candida glycerinogenes , expressing the xylitol dehydrogenase ( XYL2 ) gene, has the ability to produce glycerol from xylose entered into pentose phosphate pathway. In this study, we demonstrate that low expression levels of the XYL2 gene derived from Scheffersomyces stipitis in C. glycerinogenes is a major bottleneck in efficient xylose fermentation. Through a metabolic engineering approach using an integrative expression, XYL2 was identified as an overexpression target for improving xylose metabolism. Two recombinant strains with XYL2 overexpression were constructed to ferment a mixture of glucose and xylose simultaneously in batch fermentation. Compared with C. glycerinogenes (wild type), glycerol production from xylose by C. glycerinogenes (PURGAPX2) and C. glycerinogenes (PURGPDX2) was increased by 94.5% and 103.3%, respectively. It was also found that additional overexpression of XYL2 under the control of strong promoters in a xylose‐fermenting strain not only reduced xylitol accumulation but also increased glycerol yields. As the expression levels of XYL2 increased, the glycerol yields gradually improved from 30.6 to 63.3 g/L, whereas the xylitol yields significantly decreased from 38.7 to 19.9 g/L. These results suggest that strong expression of XYL2 is a necessary condition for developing efficient xylose‐fermenting strains. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> > <sc> d </ d </ Sc> X- XELOSE分为各种生物化学术对木质纤维素应用至关重要。 Candida甘油增生</ i>表达木糖醇脱氢酶（ xyl2 </ i>）基因，具有从进入戊糖磷酸途径的木糖中生产甘油的能力。在这项研究中，我们证明衍生自 C的甲卓氏菌钠炎的 XIG12 </ i>基因的低表达水平。甘油引起的</ i>是高效木糖发酵中的主要瓶颈。通过使用一体化表达的代谢工程方法，鉴定为改善木糖代谢的过表达靶标的代谢工程方法。构建两个具有 XIG12 </ i>过表达的重组菌株以在分批发酵中同时发酵葡萄糖和木糖的混合物。与 c相比。甘油引起的</ i>（野生型），来自木糖的甘油生产通过 C.甘油增生</ i>（purgapx2）和 c。甘油增生（PURGPDX2）分别增加了94.5％和103.3％。还发现，在木糖 - 发酵菌株的强启动子的控制下，额外过表达在木糖 - 发酵菌株中的控制下不仅降低了木糖醇累积，而且还增加了甘油产率。作为 XIL2的表达水平增加，甘油产率逐渐提高至63.3g / L，而木糖醇产率显着降低38.7至19.9g / L.这些结果表明，强烈的 xyl2 </ i>的表达是显影有效木糖发酵菌株的必要条件。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15016/'>《Biotechnology and Applied Biochemistry》</a> <b style="margin: 0 2px;">|</b><span>2017年第4期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zong Hong&option=202" target="_blank" rel="nofollow">Zong Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Cheng&option=202" target="_blank" rel="nofollow">Zhang Cheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhuge Bin&option=202" target="_blank" rel="nofollow">Zhuge Bin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Xinyao&option=202" target="_blank" rel="nofollow">Lu Xinyao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fang Huiying&option=202" target="_blank" rel="nofollow">Fang Huiying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Jin&option=202" target="_blank" rel="nofollow">Sun Jin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>The Key Laboratory of Industrial BiotechnologyJiangnan UniversityWuxi People's Republic of China;</p> <p>The Key Laboratory of Industrial BiotechnologyJiangnan UniversityWuxi People's Republic of China;</p> <p>The Key Laboratory of Industrial BiotechnologyJiangnan UniversityWuxi People's Republic of China;</p> <p>The Key Laboratory of Industrial BiotechnologyJiangnan UniversityWuxi People's Republic of China;</p> <p>The Key Laboratory of Industrial BiotechnologyJiangnan UniversityWuxi People's Republic of China;</p> <p>Zhejiang Condiments Industry Research CenterZhejiang Zhengwei Food Co. Ltd.Yiwu People's Republic of China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Candida glycerinogenes&option=203" rel="nofollow">Candida glycerinogenes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=yeast&option=203" rel="nofollow">yeast;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=xylose&option=203" rel="nofollow">xylose;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=xylitol dehydrogenase&option=203" rel="nofollow">xylitol dehydrogenase;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=glycerol&option=203" rel="nofollow">glycerol;</a> </p> <div class="translation"> 机译：念珠菌;酵母;木糖;木糖醇脱氢酶;甘油; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704021881147.html">Effects of xylitol dehydrogenase ( <i 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Effects of xylitol dehydrogenase ( XYL2XYL2 ) on xylose fermentation by engineered Candida glycerinogenesCandida glycerinogenes

摘要