Enhancing microbial production of biofuels by expanding microbial metabolic pathways

机译：通过扩增微生物代谢途径增强生物燃料的微生物生产

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Abstract > Fatty acid, isoprenoid, and alcohol pathways have been successfully engineered to produce biofuels. By introducing three genes, atfA , adhE , and pdc , into Escherichia coli to expand fatty acid pathway, up to 1.28 g/L of fatty acid ethyl esters can be achieved. The isoprenoid pathway can be expanded to produce bisabolene with a high titer of 900 mg/L in Saccharomyces cerevisiae . Short‐ and long‐chain alcohols can also be effectively biosynthesized by extending the carbon chain of ketoacids with an engineered “+1” alcohol pathway. Thus, it can be concluded that expanding microbial metabolic pathways has enormous potential for enhancing microbial production of biofuels for future industrial applications. However, some major challenges for microbial production of biofuels should be overcome to compete with traditional fossil fuels: lowering production costs, reducing the time required to construct genetic elements and to increase their predictability and reliability, and creating reusable parts with useful and predictable behavior. To address these challenges, several aspects should be further considered in future: mining and transformation of genetic elements related to metabolic pathways, assembling biofuel elements and coordinating their functions, enhancing the tolerance of host cells to biofuels, and creating modular subpathways that can be easily interconnected. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>抽象</ title> >脂肪酸，异戊二烯和酒精途径已被成功地设计以生产生物燃料。通过将三个基因引入 ATFA， adhe </ i>，和 PDC，进入<I>大肠杆菌，以膨胀脂肪酸途径可以实现1.28g / L的脂肪酸乙酯。等异戊二烯途径可以扩大以产生具有900mg / L的高滴度的二替烯，在酿酒酵母中为900mg / l。通过用工程化的“+1”醇途径延伸酮酸碳链，还可以有效地生成短链和长链醇。因此，可以得出结论，扩增微生物代谢途径具有增强生物燃料的微生物生产的巨大潜力，以供未来的工业应用。然而，应该克服与传统化石燃料的微生物生产的微生物生产的一些重大挑战：降低生产成本，减少构建遗传元素所需的时间并提高其可预测性和可靠性，以及创造具有有用和可预测的行为的可重复使用的部件。为了解决这些挑战，将来应进一步考虑以下几个方面：挖掘和转化与代谢途径相关的遗传元素，组装生物燃料元素和协调其功能，增强宿主细胞对生物燃料的耐受性，并产生可以容易地产生模块化细胞链互联。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15016/'>《Biotechnology and Applied Biochemistry》</a> <b style="margin: 0 2px;">|</b><span>2017年第5期</span><b style="margin: 0 2px;">|</b><span>共14页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Ping&option=202" target="_blank" rel="nofollow">Yu Ping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xingge&option=202" target="_blank" rel="nofollow">Chen Xingge;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Peng&option=202" target="_blank" rel="nofollow">Li Peng;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>College of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou Zhejiang Province People's Republic of China;</p> <p>College of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou Zhejiang Province People's Republic of China;</p> <p>College of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou Zhejiang Province People's Republic of China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alcohol‐derived pathway&option=203" rel="nofollow">alcohol‐derived pathway;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biofuels&option=203" rel="nofollow">biofuels;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fatty acid‐derived pathway&option=203" rel="nofollow">fatty acid‐derived pathway;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=isoprenoid‐derived pathway&option=203" rel="nofollow">isoprenoid‐derived pathway;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microbial production&option=203" rel="nofollow">microbial production;</a> </p> <div class="translation"> 机译：醇衍生的途径;生物燃料;脂肪酸衍生的途径;异戊二烯衍生的途径;微生物生产; 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