Inhibitor screening of lactate dehydrogenase C4 from black-lipped pika in the Western Sichuan Plateau

摘要

Studies indicated that lactate dehydrogenase C4 (LDH-C4) was a good target protein for development of contraceptive drugs. Virtual screening and in vitro enzyme assay using pika LDH-C4 as target protein revealed NSC61610, NSC215718, and NSC345647 with K-i of 7.8, 27, and 41 mu M separately. This study might be helpful for development of pika contraceptive drugs.