CIMmultus PrimaSThe Next-Generation Anion Exchanger for Today's mRNA-Based Vaccines

摘要

CIMmultus PrimaS multimode ligand bioprocessing technology represents a new class of anion exchangers for fast, efficient, one-step purification of single-stranded mRNA at ambient temperature.DNA, dsRNA, and proteins are eliminated with a high-salt wash. Then ssRNA is fractionated by size in a pH gradient that removes short transcripts and fragments. Convective mass transfer and laminar flow through the technology's monolithic architecture maintain high capacity, high resolution, and low shear stress — even at flow rates >5 column volumes per minute.