Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway

Su Liang; Jiang Yiming; Xu Yu; Li Xinye; Gao Wenbin; Xu Chunwei; Zeng Changqian; Song Jie; Weng Wencai; Liang Wenbo

首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway

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Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway

机译：通过上调MEKK1 / SEK1 / JNK1 / AP-1途径促进4T1小鼠乳腺癌肿瘤微环境中Treg细胞凋亡的凋亡

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摘要

Objective: To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer.

机译：目的：确定MEKK1 / SEK1 / JNK1 / AP-1通路在Xihuang丸（XHP）在4T1小鼠乳腺癌模型中降低肿瘤微环境中的调节性T（Treg）细胞数的作用中的作用，阐明乳腺癌XHP的抗肿瘤机制。

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来源
《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2018年第2018期|共9页
作者
Su Liang; Jiang Yiming; Xu Yu; Li Xinye; Gao Wenbin; Xu Chunwei; Zeng Changqian; Song Jie; Weng Wencai; Liang Wenbo;
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作者单位

Dalian Univ Xin Hua Affiliated Hosp Dalian 116000 Peoples R China;

Dalian Univ Xin Hua Affiliated Hosp Dalian 116000 Peoples R China;

Dalian Univ Med Coll Dalian 116622 Peoples R China;

Dalian Univ Med Coll Dalian 116622 Peoples R China;

Shenzhen Univ Affiliated Hosp 3 Dept Med Oncol Shenzhen 518001 Peoples R China;

Acad Mil Med Sci Affiliated Hosp Dept Pathol Beijing 100071 Peoples R China;

Dalian Univ Med Coll Dalian 116622 Peoples R China;

Dalian Univ Med Coll Dalian 116622 Peoples R China;

Dalian Univ Xin Hua Affiliated Hosp Dalian 116000 Peoples R China;

Dalian Univ Med Coll Dalian 116622 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Xihuang pill; 4T1 mouse breast cancer cell; tumor microenvironment; Treg cell; MEKK1/SEK1/JNK1/AP-1;

机译：Xihuang丸;4T1小鼠乳腺癌细胞;肿瘤微环境;Treg Cell;MEKK1 / SEK1 / JNK1 / AP-1;

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专利

1. Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway [J] . Su Liang, Jiang Yiming, Xu Yu, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：通过上调MEKK1 / SEK1 / JNK1 / AP-1途径促进4T1小鼠乳腺癌肿瘤微环境中Treg细胞凋亡的凋亡
2. The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway [J] . Xin-ye Li, Liang Su, Yi-ming Jiang, Evidence-based complementary and alternative medicine: eCAM . 2018,第10期

机译：锡黄丸对PI3K / AKT〜AP-1信号通路对4T1荷瘤小鼠肿瘤微环境中Treg细胞减少的抗肿瘤作用
3. The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT similar to AP-1 Signaling Pathway [J] . Li Xin-ye, Su Liang, Jiang Yi-ming, Evidence-based complementary and alternative medicine: eCAM . 2018,第4期

机译：通过PI3K / AKT类似于AP-1信号通路的PI3K / AKT，Xihuang丸对Treg细胞对Treg细胞的抗肿瘤效应降低
4. Curcuma zanthorrhiza Extracts Induce G2/M Cell Cycle Arrest and Apoptosis in 4T1 and MCF-7 Human Breast Cancer Cells [C] . Sari Haryanti, Galuh Ratnawati, Nuning Rahmawati International Symposium on Health Research;National Congress of The Indonesian Public Health Association . 2020

机译：Curcuma Zanthorrhiza提取物在4T1和MCF-7人乳腺癌细胞中诱导G2 / M细胞循环骤停和细胞凋亡
5. Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis [D] . Wu, Kerui. 2017

机译：癌细胞与肿瘤微环境之间的相互交流促进乳腺癌转移
6. The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway [O] . Xin-ye Li, Liang Su, Yi-ming Jiang, 2018

机译：西黄丸对PI3K / AKT〜AP-1信号通路对4T1荷瘤小鼠肿瘤微环境中Treg细胞减少的抗肿瘤作用
7. Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model [O] . Liao, Debbie, Luo, Yunping, Markowitz, Dorothy, 2009

机译：癌症相关的成纤维细胞通过调节4T1小鼠乳腺癌模型中的肿瘤免疫微环境来促进肿瘤生长和转移。
8. Gamma Synuclein Promotes a Metastatic Phenotype in Breast Cancer and Ovarian Tumor Cells by Modulating the Rho Signal Transduction Pathway [R] . Godwin, A. K. 2003

机译：γ突触核蛋白通过调节Rho信号转导途径促进乳腺癌和卵巢肿瘤细胞的转移表型

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway

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