Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake

Verheij Michel M. M.; Contet Candice; Karel Peter; Latour Judith; van der Doelen Rick H. A.; Geenen Bram; van Hulten Josephus A.; Meyer Francisca; Kozicz Tamas; George Olivier; Koob George F.; Homberg Judith R.

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Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake

机译：中位数和背部Raphe Serotonergic神经元控制中度与强迫性可卡因摄入量

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BACKGROUND: Reduced expression of the serotonin transporter (SERT) promotes anxiety and cocaine intake in both humans and rats. We tested the hypothesis that median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) serotonergic projections differentially mediate these phenotypes.

机译：背景：减少血清素转运蛋白（SERT）的表达促进了人类和大鼠的焦虑和可卡因摄入量。我们测试了中位数核（MRN）和背甲状腺核（DRN）Serotonergic突起的假设差异介导这些表型。

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来源
《Biological psychiatry》 |2018年第12期|共12页
作者
Verheij Michel M. M.; Contet Candice; Karel Peter; Latour Judith; van der Doelen Rick H. A.; Geenen Bram; van Hulten Josephus A.; Meyer Francisca; Kozicz Tamas; George Olivier; Koob George F.; Homberg Judith R.;
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作者单位

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Cognit Neurosci Nijmegen;

Scripps Res Inst Dept Neurosci La Jolla CA 92037 USA;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Cognit Neurosci Nijmegen;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Cognit Neurosci Nijmegen;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Anat Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Anat Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Mol &

Anim Physiol Nijmegen Ctr Mol Life Sci Nijmegen;

Radboud Univ Nijmegen Med Ctr Dept Mol &

Anim Physiol Nijmegen Ctr Mol Life Sci Nijmegen;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Anat Nijmegen Netherlands;

Scripps Res Inst Dept Neurosci La Jolla CA 92037 USA;

NIDA Neurobiol Addict Sect NIH Baltimore MD USA;

Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit &

Behav Dept Cognit Neurosci Nijmegen;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Anxiety-related behavior; Corticotropin-releasing factor; CRF; Dorsal raphe nucleus; Gene silencing; Knockdown; Knockout; Long access to cocaine self-administration; Median raphe nucleus; Serotonin transporter; SERT; Short access to cocaine self-administration;

机译：焦虑相关的行为;皮质大发 - 释放因子;CRF;背甲核;基因沉默;敲低;敲门;长途接入可卡因自我管理;中位罗核;血清素转运仪;SERT;SERT;SERT;短期访问可卡因自我管理;

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1. Regenerative Properties of Fetal n. Raphe Cells in Modeling Injuries of Serotonergic Neurite-Glial Fibers in Vitro [J] . Vasylyeva I. G., Oleksenko N. P., Chopyk N. G., 药剂与药理学：英文版 . 2017,第008期
2. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake [J] . Verheij Michel M. M., Contet Candice, Karel Peter, Biological psychiatry . 2018,第12期

机译：中位数和背部Raphe Serotonergic神经元控制中度与强迫性可卡因摄入量
3. Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum. [J] . Aznar S, Qian ZX, Knudsen GM Neuroscience: An International Journal under the Editorial Direction of IBRO . 2004,第3期

机译：非5-羟色胺的背侧和正中线投射到海马和隔中含小白蛋白和钙结合蛋白的神经元上。
4. Direct projections from serotonergic neurons in the dorsal and median raphe nuclei of midbrain to the suprachiasmatic nucleus in Tupaia belangeri chinensis. [J] . Su JD, Liu SY Neuroreport . 2001,第11期

机译：从中脑背侧和正中缝沟核中的血清素能神经元直接投射到中华pa中的视交叉上核。
5. Comparison of projections of the dorsal and median raphe nuclei, with some functional considerations [C] . Robert P. Vertes, Stephanie B. Linle International Study Group for Tryptophan Research . 2007

机译：多核和中位数核的投影比较，具有一些功能考虑因素
6. REGULATORY MECHANISMS AND SYNAPTIC PHARMACOLOGY OF SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS, MEDIAN RAPHE NUCLEUS AND RAPHE PALLIDUS NUCLEUS IN MOUSE BRAIN SLICES IN VITRO. [D] . CRISP, TERRIANN. 1985

机译：小鼠脑片背侧RAPHE核，中性RAPHE核和RAPHE PALLIDUS核中5-羟色胺神经元的调控机制和突触药理学。
7. Median and dorsal raphe serotonergic neurons control moderate versus compulsive cocaine intake [O] . Michel M.M. Verheij, Candice Contet, Peter Karel, -1

机译：中缝和背缝的血清素能神经元控制可卡因的摄入量与中度
8. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake [O] . Michel M.M. Verheij, Candice Contet, Peter Karel, 2018

机译：中位数和背部Raphe Serotonergic神经元控制中度与强迫性可卡因摄入量

Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake

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