Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5

摘要

Background: The clinical benefits of opioid drugs are counteracted by the development of tolerance and addiction. We provide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence in addition to their roles in agonist-selective mu-opioid receptor (MOR) phosphorylation.