Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5

Glueck Laura; Loktev Anastasia; Mouledous Lionel; Mollereau Catherine; Law Ping-Yee; Schulz Stefan

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Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5

机译：缺乏G蛋白偶联受体激酶5的小鼠中吗啡奖励的丧失和依赖性。

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Background: The clinical benefits of opioid drugs are counteracted by the development of tolerance and addiction. We provide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence in addition to their roles in agonist-selective mu-opioid receptor (MOR) phosphorylation.

机译：背景：阿片类药物的临床益处被耐受性和成瘾性的发展所抵消。我们提供体内证据，证明G蛋白偶联受体激酶（GRKs）参与阿片样物质依赖，以及它们在激动剂选择性mu阿片样受体（MOR）磷酸化中的作用。

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《Biological psychiatry》 |2014年第10期|共8页
作者
Glueck Laura; Loktev Anastasia; Mouledous Lionel; Mollereau Catherine; Law Ping-Yee; Schulz Stefan;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Bar code; conditioned place preference; dependence; G protein-coupled receptor kinase; mu opioid receptor; phosphorylation;

机译：条形码;条件位置偏好;依赖性;G蛋白偶联受体激酶;μ阿片受体;磷酸化;

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1. Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5 [J] . Glueck Laura, Loktev Anastasia, Mouledous Lionel, Biological psychiatry . 2014,第10期

机译：缺乏G蛋白偶联受体激酶5的小鼠中吗啡奖励的丧失和依赖性。
2. Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. [J] . Raehal KM, Schmid CL, Medvedev IO Drug and alcohol dependence . 2009,第3期

机译：吗啡诱导缺乏G蛋白偶联受体激酶6的小鼠的生理和行为反应
3. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. [J] . Matthes HW, Maldonado R, Simonin F, Nature . 1996,第6603期

机译：在缺乏mu阿片受体基因的小鼠中，吗啡引起的镇痛作用丧失，奖励作用和戒断症状。
4. G PROTEIN-COUPLED RECEPTOR KINASE TYPE 4 (GRK4) GENE VARIANTS AND RESPONSE TO ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER THERAPY [C] . Hironobu Sanada, Junichi Yatabe, Midori Sasaki Yatabe, 9th International Symposium on Salt(第九届世界盐业大会）论文集 . 2009

机译：G蛋白偶联的4型受体激酶（GRK4）基因变异和对血管紧张素II 1型受体阻滞剂的反应
5. G Protein-Coupled Receptor Kinase 2 (GRK2) and Toll-like Receptors as Regulators of Central Sensitization in Fibromyalgia and Chronic Temporomandibular Disorders [D] . Angkanawaraphan, Lalilta. 2018

机译：G蛋白偶联受体激酶2（GRK2）和Toll样受体作为纤维肌痛和慢性颞下颌关节疾病中枢敏化的调节剂。
6. Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5 [O] . Laura Glück, Anastasia Loktev, Lionel Moulédous, -1

机译：缺乏G蛋白偶联受体激酶5的小鼠中吗啡奖励的丧失和依赖性。
7. Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6 [O] . Kirsten M. Raehal, Cullen L. Schmid, Ivan O. Medvedev, 2009

机译：缺乏G蛋白偶联受体激酶6的小鼠中的吗啡诱导的生理行为反应

Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5

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