首页> 外文期刊>Biomechanics and modeling in mechanobiology >Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
【24h】

Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts

机译:电纺透析移植物的血液力和力学性能的计算研究

获取原文
获取原文并翻译 | 示例
       

摘要

Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft-vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear (OSI>0.25) and very high wall shear stress (>40Pa) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.
机译:据信,透析透析移植物(AVG)与连接静脉之间的顺从不匹配,导致围绕接枝 - 静脉吻合术以及静脉的机械负荷增加的血流动力学。这两种现象都与新内膜增生开发有关,这是AVG Patency损失的主要原因。在这项研究中,我们使用患者特异性的流体结构相互作用AVG模型来评估是否可以通过使用新的Electur术聚氨酯(EPU)移植物来优化AVG血流动力学和机械负载,因为它们的顺应性可以更好地调整以与本地静脉相匹配与金标准,膨胀的聚四氟乙烯(EPTFE)移植物相比。观察到EPTFE移植物的静脉中静脉紊乱和暴露于高度振荡剪切(OSI> 0.25)和非常高的壁剪切应力(> 40Pa)中最大的静脉紊乱的大小。静脉中的中值菌株和von误胁迫对于两种接枝类型相似,而在EPU移植物的吻合中观察到最高的应力和菌株。由于血管动力学最有利,因此通过使用EPU移植物可以改善AVG寿命。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号