Synthesis spherical porous hydroxyapatite/graphene oxide composites by ultrasonic-assisted method for biomedical applications

摘要

Spherical porous hydroxyapatite (SHA)/graphene oxide (GO) composites with differentGO(w/w) content of 16%, 40%, and 71% have been fabricated through a facile and controllable ultrasonicassisted method at room temperature. The products were characterized by x-ray diffraction, field emission scanning electron microscopy, thermogravimetric analysis, mechanical testing and biomimetic mineralization. Results showed SHA were covered by GO, and SHA/GOcomposites had an irregular surface with different degrees ofwrinkles. The elastic modulus and hardness of SHA/GO-3 compositeswere up to 12.45 ± 0.33 GPa and 686.67 ± 26.95MPa,which indicated that the contents ofGOhad an effect on SHA/GOcomposites. And themechanical properties of SHA/GO-2 compositeswere similar to SHA particles. The biomimeticmineralization in SBF solution showed the bone-like apatite layer on composites surface,which demonstrated that the SHA/GOmaterials had osseointegration property.Moreover, in vitro cytocompatibility of SHA/GO-2 composites and pureGOwere evaluated by cell adhesion and proliferation tests usingMC3T3-E1 cells,which demonstrated that the SHA/GOcomposites can act as a good template for the cells growth and adhesion. These results suggested that the SHA/GOcompositeswill be a promising material for biomedical application.